Disturbed zinc (Zn) homeostasis in mammals is mainly characterized by impaired bone
generation accompanied with growth retardation. However, the underlying mechanisms that …

An abnormal urine composition is a key reason for kidney stone formation, but little is known
about the roles of small metabolites in the urine during kidney stone formation. Here, we …

Kidney stone disease (KSD) is one of the most common urological diseases. The incidence
of kidney stones has increased dramatically in the last few decades. Kidney stones are …

Zinc is an essential mineral, but our understanding of its uses in the body is limited.
Capitalizing on approaches available in the model system Caenorhabditis elegans, Zhao …

Zinc (Zn) deficiency syndrome, discovered only half a century ago, first showed the
physiological significance of this trace mineral. More recent studies have shown that a …

Nephrolithiasis is an increasingly prevalent condition, especially in high income countries,
and is associated with high morbidity. Extraordinary progress in genetics made the …

Globally, over 103 million individuals are afflicted by CKD, a silent killer claiming the lives of
1.2 million people annually. CKD is characterized by five progressive stages, in which …

Kidney stones are mineral deposits in the renal calyces and pelvis that are found free or
attached to the renal papillae. They contain crystalline and organic components and are …

Context Urolithiasis has a high prevalence and recurrence rate. Prevention is key to patient
management, but risk stratification is challenging. In particular, genetic predisposition for …

Purpose: The availability of various transgenic and knockout mice provides an excellent
opportunity to better understand the pathophysiology of calcium oxalate stone disease …