The high prevalence of zinc deficiency is a global public health concern, and suboptimal
maternal zinc consumption has been associated with adverse effects ranging from impaired …

An abnormal urine composition is a key reason for kidney stone formation, but little is known
about the roles of small metabolites in the urine during kidney stone formation. Here, we …

Kidney stone disease (KSD) is one of the most common urological diseases. The incidence
of kidney stones has increased dramatically in the last few decades. Kidney stones are …

Zinc (Zn) deficiency syndrome, discovered only half a century ago, first showed the
physiological significance of this trace mineral. More recent studies have shown that a …

Zinc is an essential mineral, but our understanding of its uses in the body is limited.
Capitalizing on approaches available in the model system Caenorhabditis elegans, Zhao …

Nephrolithiasis is an increasingly prevalent condition, especially in high income countries,
and is associated with high morbidity. Extraordinary progress in genetics made the …

Kidney stones are mineral deposits in the renal calyces and pelvis that are found free or
attached to the renal papillae. They contain crystalline and organic components and are …

Context Urolithiasis has a high prevalence and recurrence rate. Prevention is key to patient
management, but risk stratification is challenging. In particular, genetic predisposition for …

Zebrafish (ZF, Danio rerio) has emerged as an important and popular model species to
study different human diseases. Key regulators of skeletal development and calcium …

Purpose: The availability of various transgenic and knockout mice provides an excellent
opportunity to better understand the pathophysiology of calcium oxalate stone disease …