Chemokine receptors are members of the G protein-coupled receptor superfamily, which
together with chemokine ligands form chemokine networks to regulate various cellular …

Background: Chemokines are chemotactic mediators that are implicated in liver diseases. In
viral hepatitis and primary biliary cirrhosis, a predominant chemokine receptor expressed in …

Liver plays a critical role in metabolism, nutrient storage and detoxification. Emergency
signals or appropriate immune response leads to pathological inflammation and breaks the …

Chemokines are a family of cytokines that orchestrate the migration and positioning of
immune cells within tissues and are critical for the function of the immune system. CCR2 …

Development of hepatocellular carcinoma (HCC) is a complex and progressive disease that
involves cycles of liver cell death, inflammation, and tissue regeneration/remodelling …

CXCL5, epithelial cell derived neutrophil attractant 78, is a CXC chemokine predominantly
expressed on epithelial cells. It has specificity for CXCR2 receptors and is involved in the …

Metastasis of liver cancer is closely linked to tumor microenvironment, in which chemokines
and their receptors act in an important role. The CXCR3, the receptor of chemokine CXCL9 …

The efficacy of the current non‑surgical treatments for advanced hepatocellular carcinoma
(HCC) remains limited and novel treatments are required to improve patient outcomes. The …

Expression of the chemokine stromal cell-derived factor-1α (SDF-1α) is absent from many
carcinomas, including hepatomas. We note an early signalling defect in the hepatocellular …

Chemokines (CKs), small proinflammatory chemoattractant cytokines that bind to specific G-
protein coupled seven-span transmembrane receptors, are major regulators of cell …