Paradigm shift of therapeutic management of brain metastases in EGFR-mutant non-small cell lung cancer in the era of targeted therapy

A Sekine, H Satoh - Medical Oncology, 2017 - Springer
Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR)
mutations commonly present brain metastases (BM) at the time of NSCLC diagnosis or …

A neuro-oncologist's perspective on management of brain metastases in patients with EGFR mutant non-small cell lung cancer

T McGranahan, S Nagpal - Current Treatment Options in Oncology, 2017 - Springer
Opinion statement Management of non-small cell lung cancer (NSCLC) with brain
metastasis (BrM) has been revolutionized by identification of molecular subsets that have …

Multiple treatment modalities for brain metastasis in patients with EGFR-mutant non-small-cell lung cancer

H Wang, X Yu, Y Fan, Y Jiang - OncoTargets and therapy, 2018 - Taylor & Francis
Background There are many controversies concerning the best management of epidermal
growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) patients with …

[HTML][HTML] Treatment modes for EGFR mutations in patients with brain metastases from non-small cell lung cancer: controversy, causes, and solutions

H Zhuang, S Shi, JY Chang - Translational lung cancer research, 2019 - ncbi.nlm.nih.gov
Brain metastasis from non-small cell lung cancer (NSCLC) with epidermal growth factor
receptor (EGFR) mutations is a hot research topic, but also a difficulty in targeted NSCLC …

[HTML][HTML] Cranial irradiation in patients with EGFR-mutant non-small cell lung cancer brain metastases

TJ Yang, AJ Wu - Translational Lung Cancer Research, 2016 - ncbi.nlm.nih.gov
The most effective treatment approach for brain metastases in patients with non-small cell
lung cancer (NSCLC) and activating epidermal growth factor receptor (EGFR) mutations is a …

Commentary: treatment considerations for patients with epidermal growth factor receptor-mutated non-small cell lung cancer brain metastases in the era of tyrosine …

SD Vaca, ID Connolly, C Ho, J Neal, MH Gephart - Neurosurgery, 2018 - journals.lww.com
Brain metastasis is a serious complication of non-small cell lung cancer (NSCLC) affecting
up to 40% of NSCLC patients. A subset of NSCLC tumors has mutations in the epidermal …

[HTML][HTML] Complete remission of brain metastases in non-small cell lung cancer patients harboring an EGFR mutation treated with tyrosine kinase inhibitor without …

YH Jung, CW Han, YD Jung, YY Cho… - Case Reports in …, 2014 - karger.com
Brain parenchymal metastasis from a solid tumor is a serious clinical condition associated
with a poor outcome because systemic chemotherapy is usually ineffective for treating brain …

EGF receptor tyrosine kinase inhibitors in the treatment of brain metastases from non-small-cell lung cancer

M Bartolotti, E Franceschi… - Expert review of anticancer …, 2012 - Taylor & Francis
The incidence of brain metastasis (BM) is high in patients with non-small-cell lung cancer.
Available standard therapeutic options, such as whole-brain radiation therapy and systemic …

Combination of EGFR-Directed Tyrosine Kinase Inhibitors (EGFR-TKI) with Radiotherapy in Brain Metastases from Non-Small Cell Lung Cancer: A 2010–2019 …

V Tatineni, PJ O'Shea, S Saxena, AA Khosla, A Ozair… - Cancers, 2023 - mdpi.com
Simple Summary Radiotherapy, in the form of either whole-brain radiotherapy (WBRT) or
stereotactic radiosurgery (SRS), continues as the standard of care for patients of non-small …

CNS metastases in non-small-cell lung cancer: current role of EGFR-TKI therapy and future perspectives

LA Berger, H Riesenberg, C Bokemeyer… - Lung Cancer, 2013 - Elsevier
A considerable proportion of non-small-cell lung cancer (NSCLC) patients will develop
central nervous system (CNS) metastases throughout the course of their disease and these …