Problems during DNA replication underlie genomic instability and drive malignant
transformation. The DNA damage checkpoint stabilizes stalled replication forks thus …

The S-phase checkpoint is involved in coupling DNA unwinding with nascent strand
synthesis and is critical to maintain replication fork stability in conditions of replicative stress …

Stalled DNA replication fork restart after stress as orchestrated by ATR kinase, BLM
helicase, and structure-specific nucleases enables replication, cell survival, and genome …

The replication checkpoint coordinates the cell cycle with DNA replication and
recombination, preventing genome instability and cancer. The budding yeast Rad53 …

Accurate DNA replication is essential to preserve genomic integrity and prevent
chromosomal instability-associated diseases including cancer. Key to this process is the …

Abnormal processing of stressed replication forks by nucleases can cause fork collapse,
genomic instability, and cell death. Despite its importance, it is poorly understood how the …

When replication forks stall at damaged bases or upon nucleotide depletion, the intra-S
phase checkpoint ensures they are stabilized and can restart. In intra-S checkpoint-deficient …

Single-stranded DNA (ssDNA) at DNA ends is an important regulator of the DNA damage
response. Resection, the generation of ssDNA, affects DNA damage checkpoint activation …

Replication fork reversal occurs via a two-step process that entails reversal initiation and
reversal extension. DNA topoisomerase IIalpha (TOP2A) facilitates extensive fork reversal …

Replication fork reversal is a global response to replication stress in mammalian cells, but
precisely how it occurs remains poorly understood. Here, we show that, upon replication …