Duchenne muscular dystrophy is caused by mutations in the dystrophin gene and is
characterized by progressive muscle wasting. A number of Duchenne patients also present …

Mutations in the human dystrophin gene cause the Duchenne and Becker muscular
dystrophies. The Dystrophin protein provides a structural link between the muscle …

The dystrophin–glycoprotein complex (DGC) links the cytoskeleton of muscle fibers to their
extracellular matrix. Using knockout mice, we show that a cytoplasmic DGC component, α …

The proper function of skeletal muscles relies on their ability to process signals derived from
motor neurons, transmit stimuli along the muscle fibers, contract, and regenerate efficiently …

Duchenne muscular dystrophy (DMD), the most common inherited neuromuscular disorder,
is characterized by progressive muscle wasting and weakness. One third of Duchenne …

Dystrophinopaties, eg, Duchenne muscular dystrophy (DMD), Becker muscular dystrophy
and X-linked dilated cardiomyopathy are inherited neuromuscular diseases, characterized …

Duchenne muscular dystrophy (DMD) is an X‐linked myopathy caused by dystrophin
deficiency. Dystrophin is present intracellularly at the sarcolemma, connecting actin to the …

Abstract The Dystrophin Glycoprotein Complex (DGC) is a large multi-protein complex that
links cytoskeleton actin to the extracellular matrix. This complex is critical in maintaining the …

In muscle, dystrophin anchors a complex of proteins at the cell surface which includes α‐
dystroglycan, β‐dystroglycan, syntrophins and dystrobrevins. Mutations in the dystrophin …

Background The Dystrophin-glycoprotein complex (DGC) comprises dystrophin,
dystroglycan, sarcoglycan, dystrobrevin and syntrophin subunits. In muscle fibers, it is …