We studied the association between clinical outcome in MS and allelic variants single
nucleotide polymorphisms (SNPs) of interleukin-1α (IL-1α), IL-1β and a variable number …

We have investigated the association of two single nucleotide polymorphisms (SNPs) at
positions− 384 and 114 in the human interleukin-2 (hIL-2) with multiple sclerosis (MS). For …

Multiple sclerosis (MS) is a chronic disease of presumed autoimmune origin with a
considerable polygenic influence. We have previously observed that a specific allele …

Background: Multiple sclerosis (MS) is an autoimmune disorder, with a considerable genetic
influence on susceptibility and disease course. Cytokines play an important role in MS …

An epistatic gene interaction has been advocated to explain disease susceptibility in
multiple sclerosis (MS). Cytokine genes are possible candidates due to the central role …

The autoimmune nature of multiple sclerosis introduces cytokine genes as logical
candidates for the loci determining susceptibility to the disease, and/or influencing disease …

We studied the putative association of a C→ T polymorphism in exon-5 of IL-1β and an 85
bp tandem repeat in intron-4 of IL-1 receptor antagonist (IL-1ra) genes with susceptibility to …

Differential expression of interleukins may influence susceptibility to inflammatory diseases
such as MS. IL-1a production is increased in MS patients during acute relapse, IL-2 receptor …

Interleukin-10 (IL-10) secretion affects the inducibility of experimental autoimmune
encephalomyelitis and the outcome of multiple sclerosis (MS). Here, we report that a G to A …

Previous studies have suggested a role for interleukin-4 gene (IL4) in susceptibility to
multiple sclerosis (MS) as well as other autoimmune diseases. We screened the promoter …