Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women

DJ Thompson, CS Healey, C Baynes… - … Biomarkers & Prevention, 2008 - AACR
Background: Circulating levels of sex hormone-binding globulin (SHBG) are inversely
associated with breast cancer risk in postmenopausal women. Three polymorphisms within …

Prospective association of serum androgens and sex hormone-binding globulin with subclinical cardiovascular disease in young adult women: the “Coronary Artery …

R Calderon-Margalit, SM Schwartz… - The Journal of …, 2010 - academic.oup.com
Context: The role of endogenous androgens and SHBG in the development of
cardiovascular disease in young adult women is unclear. Objective: Our objective was to …

Sex hormone-binding globulin, genetic susceptibility, and the risk of type 2 diabetes in men and postmenopausal women

W Zhang, H Zhang, B Wang, Y Wang… - Chinese Medical …, 2023 - mednexus.org
To the Editor: Type 2 diabetes (T2D) is one of the most common and fastest growing non-
communicable diseases worldwide. Sex hormone-binding globulin (SHBG) is a circulating …

[HTML][HTML] Sex hormone-binding globulin and heart failure hospitalizations in patients with dysglycemia: Experiences from the outcome reduction with an Initial Glargine …

A Wang, S Hess, SF Lee, HC Gerstein - Diabetes Research and Clinical …, 2023 - Elsevier
Introduction Sex hormone-binding globulin (SHBG), which binds most of circulating
testosterone in blood, has been linked to dysglycemia and cardiovascular disease but the …

Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank

K Harris, SAE Peters, M Woodward - Biology of sex Differences, 2023 - Springer
Objectives There is conflicting evidence around the role of sex hormones with
cardiovascular outcomes. The aim of this study was to examine the association of sex …

Sex hormone–binding globulin as an independent predictor of incident type 2 diabetes mellitus in men

KM Lakshman, S Bhasin… - Journals of Gerontology …, 2010 - academic.oup.com
Background. Low levels of sex hormone–binding globulin (SHBG) and total testosterone (T)
in men have been associated with increased risk of type 2 diabetes mellitus (T2DM). As total …

Sex hormone levels–estradiol, testosterone, and sex hormone binding globulin as a risk marker for atherosclerotic coronary artery disease in post-menopausal …

DV Das, UK Saikia, D Sarma - Indian journal of endocrinology and …, 2019 - journals.lww.com
Aims: To investigate the relationship between sex hormones (estradiol and testosterone)/sex
hormone binding globulin (SHBG) and cardiovascular risk factors in PM women. In addition …

The relationship of sex hormone-binding globulin (SHBG) gene polymorphisms with serum SHBG level and metabolic syndrome in Chinese Han males

XN Pang, Y Yuan, Y Sun, JP Shen, XY Zha… - Aging Clinical and …, 2014 - Springer
Objective Epidemiological studies have shown that circulating sex hormone-binding
globulin (SHBG) levels are lower in metabolic syndrome (MetS) patients than in non-MetS …

Low levels of sex hormone-binding globulin predict an increased breast cancer risk and its underlying molecular mechanisms

S Zhao, J Gu, Y Tian, R Wang, W Li - Open Life Sciences, 2024 - degruyter.com
Sex hormone-binding globulin (SHBG) is a serum glycoprotein exhibiting the unique feature
of binding sex steroids with high affinity and specificity. Over the past few decades, there …

Associations between serum sex hormone concentrations and whole blood gene expression profiles in the general population

R Haring, C Schurmann, G Homuth, L Steil, U Völker… - PloS one, 2015 - journals.plos.org
Background Despite observational evidence from epidemiological and clinical studies
associating sex hormones with various cardiometabolic risk factors or diseases …