Epstein‐Barr virus‐driven metabolic alterations contribute to the viral lytic reactivation and tumor progression in nasopharyngeal carcinoma

F Shi, L Shang, M Zhou, C Lv, Y Li… - Journal of Medical …, 2024 - Wiley Online Library
Metabolic reprogramming induced by Epstein‐Barr virus (EBV) often mirrors metabolic
changes observed in cancer cells. Accumulating evidence suggests that lytic reactivation is …

EBV infection and its regulated metabolic reprogramming in nasopharyngeal tumorigenesis

T Yang, C You, S Meng, Z Lai, W Ai… - Frontiers in Cellular and …, 2022 - frontiersin.org
Viral oncogenes may drive cellular metabolic reprogramming to modulate the normal
epithelia cell malignant transformation. Understanding the viral oncogene–mediated …

EBV infection and glucose metabolism in nasopharyngeal carcinoma

J Zhang, L Jia, CM Tsang, SW Tsao - Infectious Agents Associated …, 2017 - Springer
To establish persistent infection in cells, viruses evolve strategies to alter host cellular
pathways to regulate cell proliferation and energy metabolism which support viral infection …

Targeting Epstein–Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy

L Xiao, ZY Hu, X Dong, Z Tan, W Li, M Tang, L Chen… - Oncogene, 2014 - nature.com
Our goal in this work was to illustrate the Epstein-Barr virus (EBV)-modulated global
biochemical profile and provide a novel metabolism-related target to improve the therapeutic …

Cytolytic virus activation therapy and treatment monitoring for Epstein‐Barr virus associated nasopharyngeal carcinoma in a mouse tumor model

Z Novalić, SAWM Verkuijlen, M Verlaan… - Journal of Medical …, 2017 - Wiley Online Library
Undifferentiated nasopharyngeal carcinoma (NPC) is 100% associated with Epstein‐Barr
virus (EBV). Expression of viral proteins in the tumor cells is highly restricted. EBV …

Targeting Epstein-Barr virus in nasopharyngeal carcinoma

PM Hau, HL Lung, M Wu, CM Tsang, KL Wong… - Frontiers in …, 2020 - frontiersin.org
Nasopharyngeal carcinoma (NPC) is consistently associated with Epstein-Barr virus (EBV)
infection in regions in which it is endemic, including Southern China and Southeast Asia …

EBV abortive lytic cycle promotes nasopharyngeal carcinoma progression through recruiting monocytes and regulating their directed differentiation

X Xu, N Zhu, J Zheng, Y Peng, MS Zeng, K Deng… - Plos …, 2024 - journals.plos.org
Epstein-Barr virus (EBV) is associated with several types of human cancer including
nasopharyngeal carcinoma (NPC). The activation of EBV to the lytic cycle has been …

Perspective: contribution of epstein–barr virus (EBV) reactivation to the carcinogenicity of nasopharyngeal cancer cells

CC Wu, CY Fang, SY Huang, SH Chiu, CH Lee… - Cancers, 2018 - mdpi.com
Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma derived from the
epithelium of the post-nasal cavity, with a unique geographic and ethnic distribution. Epstein …

Intermittent abortive reactivation of Epstein-Barr virus during the progression of nasopharyngeal cancer as indicated by elevated antibody levels

X Guo, T Li, F Li, Y Xu, H Wang, W Cheng, J Tang… - Oral Oncology, 2019 - Elsevier
The development of nasopharyngeal carcinoma (NPC), a common cancer in Southeastern
Asia, is closely associated with Epstein-Barr virus (EBV) infection; however, the aetiological …

DNMT1 mediates metabolic reprogramming induced by Epstein–Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma

X Luo, L Hong, C Cheng, N Li, X Zhao, F Shi… - Cell Death & …, 2018 - nature.com
Cancer cells frequently adapt fundamentally altered metabolism to support tumorigenicity
and malignancy. Epigenetic and metabolic networks are closely interactive, in which DNA …