A novel analysis method for biomarker identification based on horizontal relationship: identifying potential biomarkers from large-scale hepatocellular carcinoma …

B Su, P Luo, Z Yang, P Yu, Z Li, P Yin, L Zhou… - Analytical and …, 2019 - Springer
Omics techniques develop quickly and have made a great contribution to disease study.
Omics data are usually complex. How to analyze the data and mine important information …

Metabolomics identifies biomarker pattern for early diagnosis of hepatocellular carcinoma: from diethylnitrosamine treated rats to patients

J Zeng, X Huang, L Zhou, Y Tan, C Hu, X Wang, J Niu… - Scientific reports, 2015 - nature.com
Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date.
Characteristic metabolic deregulations of HCC may enable novel biomarkers discovery for …

Metabolomic characterization of hepatocellular carcinoma in patients with liver cirrhosis for biomarker discovery

C Di Poto, A Ferrarini, Y Zhao, RS Varghese, C Tu… - … Biomarkers & Prevention, 2017 - AACR
Background: Metabolomics plays an important role in providing insight into the etiology and
mechanisms of hepatocellular carcinoma (HCC). This is accomplished by a comprehensive …

[HTML][HTML] Establishment of a pattern recognition metabolomics model for the diagnosis of hepatocellular carcinoma

PC Zhou, LQ Sun, L Shao, LZ Yi, N Li… - World Journal of …, 2020 - ncbi.nlm.nih.gov
BACKGROUND Early diagnosis of hepatocellular carcinoma may help to ensure that
patients have a chance for long-term survival; however, currently available biomarkers lack …

Comprehensive metabolomic search for biomarkers to differentiate early stage hepatocellular carcinoma from cirrhosis

DJ Kim, EJ Cho, KS Yu, IJ Jang, JH Yoon, T Park… - Cancers, 2019 - mdpi.com
The established biomarker for hepatocellular carcinoma (HCC), serum α-fetoprotein (AFP),
has suboptimal performance in early disease stages. This study aimed to develop a …

Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis

HW Ressom, JF Xiao, L Tuli, RS Varghese, B Zhou… - Analytica chimica …, 2012 - Elsevier
Characterizing the metabolic changes pertaining to hepatocellular carcinoma (HCC) in
patients with liver cirrhosis is believed to contribute towards early detection, treatment, and …

Metabolomics study of hepatocellular carcinoma: discovery and validation of serum potential biomarkers by using capillary electrophoresis–mass spectrometry

J Zeng, P Yin, Y Tan, L Dong, C Hu… - Journal of proteome …, 2014 - ACS Publications
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. The lack of effective
screening methods for early diagnosis has been a longstanding bottleneck to improve the …

Metabolomic estimation of the diagnosis of hepatocellular carcinoma based on ultrahigh performance liquid chromatography coupled with time-of-flight mass …

YF Li, S Qiu, LJ Gao, AH Zhang - RSC advances, 2018 - pubs.rsc.org
Metabolomics has been shown to be an effective tool for biomarker screening and pathway
characterization and disease diagnosis. Metabolic characteristics of hepatocellular …

NMR and LC/MS‐based global metabolomics to identify serum biomarkers differentiating hepatocellular carcinoma from liver cirrhosis

Y Liu, Z Hong, G Tan, X Dong, G Yang… - … journal of cancer, 2014 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world.
However, current biomarkers that discriminate HCC from liver cirrhosis (LC) are important …

Non-targeted metabolomics study for discovery of hepatocellular carcinoma serum diagnostic biomarker

S Wang, T He, H Wang - Journal of Pharmaceutical and Biomedical …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most prevalent malignant cancers worldwide.
Due to the asymptomatic features of HCC at early stages, patients are often diagnosed at …