Saroglitazar, a PPAR‐α/γ agonist, for treatment of NAFLD: a randomized controlled double‐blind phase 2 trial
S Gawrieh, M Noureddin, N Loo, R Mohseni… - …, 2021 - Wiley Online Library
Background and Aims NAFLD is characterized by insulin resistance and dysregulated lipid
and glucose metabolism. Saroglitazar, a dual peroxisome proliferator activated receptor‐α/γ …
and glucose metabolism. Saroglitazar, a dual peroxisome proliferator activated receptor‐α/γ …
Dual PPAR α/γ agonist Saroglitazar improves liver histopathology and biochemistry in experimental NASH models
Abstract Background & Aims Non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic
steatohepatitis (NASH) are common clinico‐pathological conditions that affect millions of …
steatohepatitis (NASH) are common clinico‐pathological conditions that affect millions of …
[PDF][PDF] Modulation of insulin resistance in nonalcoholic fatty liver disease
RS Khan, F Bril, K Cusi, PN Newsome - Hepatology, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) has an estimated prevalence of 25% in the general
population, and cirrhosis secondary to nonalcoholic steatohepatitis (NASH) is predicted to …
population, and cirrhosis secondary to nonalcoholic steatohepatitis (NASH) is predicted to …
Randomised clinical trial: pemafibrate, a novel selective peroxisome proliferator‐activated receptor α modulator (SPPARMα), versus placebo in patients with non …
A Nakajima, Y Eguchi, M Yoneda… - Alimentary …, 2021 - Wiley Online Library
Background Pemafibrate is a novel, selective peroxisome proliferator‐activated receptor α
modulator (SPPARMα). In mice, Pemafibrate improved the histological features of non …
modulator (SPPARMα). In mice, Pemafibrate improved the histological features of non …
[HTML][HTML] A randomized, controlled trial of the pan-PPAR agonist lanifibranor in NASH
SM Francque, P Bedossa, V Ratziu… - … England Journal of …, 2021 - Mass Medical Soc
Background Management of nonalcoholic steatohepatitis (NASH) is an unmet clinical need.
Lanifibranor is a pan-PPAR (peroxisome proliferator–activated receptor) agonist that …
Lanifibranor is a pan-PPAR (peroxisome proliferator–activated receptor) agonist that …
[HTML][HTML] Saroglitazar in patients with non-alcoholic fatty liver disease and diabetic dyslipidemia: a prospective, observational, real world study
Saroglitazar, a dual peroxisome proliferator activated receptor α/γ agonist, approved for
diabetic dyslipidemia (DD), is potential therapeutic option for non-alcoholic fatty liver …
diabetic dyslipidemia (DD), is potential therapeutic option for non-alcoholic fatty liver …
[HTML][HTML] A new perspective on NAFLD: Focusing on the crosstalk between peroxisome proliferator-activated receptor alpha (PPARα) and farnesoid X receptor (FXR)
S Zhou, H You, S Qiu, D Yu, Y Bai, J He, H Cao… - Biomedicine & …, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is primarily caused by abnormal lipid metabolism
and the accumulation of triglycerides in the liver. NAFLD is also associated with hepatic …
and the accumulation of triglycerides in the liver. NAFLD is also associated with hepatic …
[HTML][HTML] Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic …
Background Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis
(NASH) have become significant global health concerns. In the present study, we aimed to …
(NASH) have become significant global health concerns. In the present study, we aimed to …
[PDF][PDF] Hepatoprotective effects of the dual peroxisome proliferator‐activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease …
Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver damage ranging from
simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. To date, no …
simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. To date, no …
Elafibranor: a potential drug for the treatment of nonalcoholic steatohepatitis (NASH)
MJ Westerouen Van Meeteren, JPH Drenth… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Nonalcoholic fatty liver disease (NAFLD) encompasses a progressive disease
phenotype starting from simple steatosis, which can progress to nonalcoholic steatohepatitis …
phenotype starting from simple steatosis, which can progress to nonalcoholic steatohepatitis …