N-[3-(4-Oxo-3, 4-dihydro-phthalazin-1-yl) phenyl]-4-(morpholin-4-yl) butanamide
methanesulfonate monohydrate (ONO-1924H) is a novel inhibitor of poly ADP-ribose …

Focal cerebral ischemia activates the nuclear protein poly (ADP-ribose) polymerase (PARP)
by single DNA strand breaks which leads to energy depletion and cell necrosis. Deletion or …

Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) in response to DNA damage is
considered to play a crucial role in the development of post-ischemic neuronal injury, such …

It is reported that ischemic brain injury is mediated by the activation of poly (ADP-ribose)
polymerase (PARP). In this study, we examined the pharmacological profile of KCL-440, a …

Cerebral ischemia induces excessive activation of poly (ADP-ribose) polymerase-1 (PARP-
1), leading to neuronal cell death and the development of post-ischemic dysfunction …

Excessive activation of poly (ADP‐ribose) polymerase‐1 (PARP‐1) is known to develop
neuronal apoptosis, necrosis and inflammation after ischaemic brain injury. Therefore …

Abstract Poly (ADP‐ribose) polymerase (PARP) plays an important role in ischaemic cell
death, and 3‐aminobenzamide (3‐AB), one of the PARP inhibitors, has a protective effect on …

In patients with stroke and neurodegenerative diseases, overactivation of poly (ADP-ribose)
polymerase-1 (PARP-1) causes harmful effects by inducing apoptosis, necrosis …

Poly (adenosine 5′-diphosphoribose) synthetase (PARS) has been described as an
important candidate for mediation of neurotoxicity by nitric oxide. In the current study, we …