Resveratrol functions as an agonist for estrogen receptor (ER)-mediated transcription.
However, other researchers have reported that resveratrol decreases proliferation of breast …

Abstract Sirtuin 1 (SIRT1) is a deacetylase enzyme that plays crucial roles in controlling
many cellular processes and its downregulation has been implicated in different metabolic …

Resveratrol (Resv) has antitumorigenic and antimetastatic activities; however, the molecular
mechanisms underlying the inhibitory effects of Resv on the invasion and metastasis of …

Resveratrol (RES), a polyphenolic compound present in grapes and red wine, has potential
anticancer properties. The present study aimed to examine the effects of resveratrol and its …

Sirt1 is a NAD+-dependent protein-modifying enzyme involved in regulating gene
expression, DNA damage repair, metabolism and survival, as well as acts as an important …

Abstract Sirtuin-1 (SIRT1) possesses apparently dual roles in regulation of tumor. Previous
reports have documented the crosstalk between SIRT1 with signal transducer and activator …

Objective The aim of this study was to evaluate the effect of different natural substances on
SIRT1 expression and on AMPK and mTOR phosphorylation. Moreover, we investigated the …

Despite the promising effects of resveratrol, its efficacy in the clinic remains controversial.
We were the first group to report that the SIRT1 activator resveratrol activates AMP-activated …

Sirtuins (SIRTs) overexpression serves as a potential therapeutic target for TNBC because it
is associated with bioactivities of cancer stem cells (CSCs), resistance to chemotherapy, and …

AIMS: Resveratrol, a silent information regulator 1 (SIRT1) activator, has been reported to
act as an antioxidant contained in red wine and prevent the development of cardiovascular …