New therapeutic targets, agents, and strategies are needed to prevent and treat heart failure
(HF) after a decade of failed research efforts to improve long-term patient outcomes …

With a prolonged cardiovascular stress or pathophysiologic stimuli, a cascade of structural
events occurs, defined as myocardial remodeling, as a continuum of changes in the …

In contrast to public perception, the morbidity and mortality and the resultant healthcare
costs associated with chronic heart failure (HF) are increasing and arguably reaching …

The cardiac extracellular matrix (ECM) provides the architectural scaffold to support efficient
contraction and relaxation of cardiomyocytes. The elegant design of the ECM facilitates …

Quantifying myocardial fibrosis (MF) with myocardial extracellular volume measures
acquired during cardiovascular magnetic resonance promises to transform clinical care by …

Myocardial interstitial fibrosis contributes to left ventricular dysfunction leading to the
development of heart failure. Basic research has provided abundant evidence for the …

Background—Myocardial extracellular volume (ECV) accumulation is one of the key
pathophysiologic features of heart failure with preserved ejection fraction (HFpEF). Our aims …

Pathological left ventricular hypertrophy is a common feature of many cardiac diseases. It
results from both myocyte hypertrophy and interstitial expansion. Interstitial expansion is …

Myocardial interstitial fibrosis is part of the advanced disease stage of most cardiovascular
pathologies. It has been characterized histologically in various disease settings from …

The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …