Volume overload-induced heart failure results in progressive left ventricular remodeling
characterized by chamber dilation, eccentric cardiac myocyte hypertrophy and changes in …

Myocardial recovery in heart failure (HF) is possible, but its determinants are not fully
defined. At least partial functional improvement is possible with current evidence-based …

Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and
death. Myocardial fibrosis results from increased myofibroblast activity and excessive …

Background: Only limited data exist describing the histologic and noncardiomyocyte function
of human myocardium in end-stage heart failure (HF). Objectives: The authors sought to …

Background: Cardiac magnetic resonance techniques permit quantification of the
myocardial extracellular volume fraction (ECV), representing a surrogate marker of reactive …

Background Nationally, symptomatic heart failure affects 1.5-2% of Canadians, incurs $3
billion in hospital costs annually and the global burden is expected to double in the next 1–2 …

Heart failure (HF) is a major and growing cause of morbidity and mortality. Despite initial
successes, there have been few recent therapeutic advances. A better understanding of HF …

The insight that decreases in left ventricular (LV) volume and mass occur secondary to the
recovery of the myocardium at the cellular and molecular level has engendered a wider …

Importance Among myriad changes occurring during the evolution of heart failure with
preserved ejection fraction (HFpEF), cardiomyocyte–extracellular matrix interactions from …

The cardiac extracellular matrix (ECM) maintains the structural and mechanical integrity of
the myocardium. We determined the alterations in the composition of the ECM coincident …