Chronic heart failure (CHF) is a growing health problem in developed nations. The
pathological accumulation of extracellular matrix is a key contributor to CHF in both diabetic …

The myocardial interstitial or extracellular space exists as a complex and dynamic
environment, vital for normal cardiac structure and function. The physiological pathways for …

The limited myocardial fibre thickening and shortening alone cannot explain the marked left
ventricular (LV) volume reduction during LV ejection. This can only be achieved with LV …

The myocardial extracellular matrix (ECM), which preserves the geometry and integrity of the
myocardium, is a dynamic structure whose component proteins are maintained by a finely …

Natural history studies in heart failure have shown that increases in left ventricular (LV)
volume and LV mass are directly related to future deterioration in LV performance and a less …

Background Increased myocardial fibrosis may play a key role in heart failure with preserved
ejection fraction (HFpEF) pathophysiology. The study aim was to evaluate the presence …

Background: A major advance in understanding the pathophysiology of the heart failure
syndrome has been an understanding of the process of left ventricular (LV) remodeling. After …

To better understand heart failure with preserved ejection fraction (HFpEF), we need to
better characterize the transition from asymptomatic pre-HFpEF to symptomatic HFpEF. The …

Heart failure with reduced ejection fraction (HFrEF) is a progressive disorder whereby
cardiac structure and function continue to deteriorate, often despite the absence of clinically …

The extracellular matrix (ECM) is a complex and dynamic scaffold that maintains tissue
structure and dynamics. However, the view of the ECM as an inert architectural support has …