In an attempt to compensate for compromised hemodynamics in heart failure, neurohumoral
mechanisms are activated that trigger fundamental changes in gene expression and in …

The syndrome of heart failure has traditionally been viewed as a functional disorder
precipitated by impaired left ventricular pump performance. The classification into systolic …

Background Global longitudinal strain (GLS), most commonly measured at the endocardium,
has been shown to be superior to left ventricular (LV) ejection fraction (LVEF) for the …

Abstract Purpose of Review Ischemic cardiomyopathy refers to systolic left ventricular
dysfunction in the setting of obstructive coronary artery disease and represents the most …

Heart failure results not only from cardiac overload or injury but also from a complex
interplay among genetic, neurohormonal, inflammatory, and biochemical changes acting on …

Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis,
resulting from the excessive deposition of collagen fibers, is a common feature across the …

Multicellular organisms are built of cells embedded in the interstitium, the scaffolding of
organs and tissues. In disease, the ratio between cells and interstitium changes due to …

BACKGROUND: Inflammatory pathways may promote extracellular matrix (ECM)
remodeling and chronic heart failure (CHF) progression. The relationship between markers …

Despite declines in heart failure morbidity and mortality with current therapies, re-
hospitalization rates remain distressingly high, impacting substantially on individuals …

In response to injury, hemodynamic changes, or neurohormonal activation, the heart
undergoes a series of structural and functional changes that have been termed cardiac …