Functional assays for measuring the catalytic activity of ribosome inactivating proteins
Ribosome-inactivating proteins (RIPs) are potent toxins that inactivate ribosomes by
catalytically removing a specific adenine from the α-sarcin/ricin loop (SRL) of the large …
catalytically removing a specific adenine from the α-sarcin/ricin loop (SRL) of the large …
Development of a quantitative RT-PCR assay to examine the kinetics of ribosome depurination by ribosome inactivating proteins using Saccharomyces cerevisiae as …
M Pierce, JN Kahn, J Chiou, NE Tumer - Rna, 2011 - rnajournal.cshlp.org
Ricin produced by the castor bean plant and Shiga toxins produced by pathogenic
Escherichia coli (STEC) and Shigella dysenteriae are type II ribosome inactivating proteins …
Escherichia coli (STEC) and Shigella dysenteriae are type II ribosome inactivating proteins …
Identification of a novel functional domain of ricin responsible for its potent toxicity
J Dai, L Zhao, H Yang, H Guo, K Fan, H Wang… - Journal of Biological …, 2011 - ASBMB
Ribosome-inactivating proteins (RIPs) are toxic N-glycosidases that depurinate the
universally conserved α-sarcin loop of large rRNAs. They have received attention in …
universally conserved α-sarcin loop of large rRNAs. They have received attention in …
Evidence for the importance of electrostatics in the function of two distinct families of ribosome inactivating toxins
AV Korennykh, CC Correll, JA Piccirilli - Rna, 2007 - rnajournal.cshlp.org
α-Sarcin and ricin represent two structurally and mechanistically distinct families of site-
specific enzymes that block translation by irreversibly modifying the sarcin/ricin loop (SRL) of …
specific enzymes that block translation by irreversibly modifying the sarcin/ricin loop (SRL) of …
Interaction of ricin and Shiga toxins with ribosomes
Ricin and Shiga toxins designated as ribosome inactivating proteins (RIPs) are RNA N-
glycosidases that depurinate a specific adenine (A 4324 in rat 28S rRNA) in the conserved α …
glycosidases that depurinate a specific adenine (A 4324 in rat 28S rRNA) in the conserved α …
Biological activities of ribosome-inactivating proteins
L Citores, JM Ferreras - Toxins, 2023 - mdpi.com
After more than 50 years of research, studies on the structure and biological activities of
ribosome-inactivating proteins (RIPs) continue to provide a field of great interest within the …
ribosome-inactivating proteins (RIPs) continue to provide a field of great interest within the …
Small-molecule inhibitor leads of ribosome-inactivating proteins developed using the doorstop approach
YP Pang, JG Park, S Wang, A Vummenthala… - PLoS …, 2011 - journals.plos.org
Ribosome-inactivating proteins (RIPs) are toxic because they bind to 28S rRNA and
depurinate a specific adenine residue from the α-sarcin/ricin loop (SRL), thereby inhibiting …
depurinate a specific adenine residue from the α-sarcin/ricin loop (SRL), thereby inhibiting …
Ribosomal RNA N-glycosylase activity assay of ribosome-inactivating proteins
Ribosome-inactivating proteins (RIPs) are enzymes that irreversibly inactivate ribosomes as
a consequence of their N-glycosylase (EC 3.2. 2.22) activity. The enzyme cleaves the N …
a consequence of their N-glycosylase (EC 3.2. 2.22) activity. The enzyme cleaves the N …
Ribosome Inactivating Proteins from an evolutionary perspective
WJ Lapadula, MJ Ayub - Toxicon, 2017 - Elsevier
Abstract Ribosome Inactivating Proteins (RIPs) are rRNA N-glycosidases that inhibit protein
synthesis through the elimination of a single adenine residue from 28S rRNA. Many of these …
synthesis through the elimination of a single adenine residue from 28S rRNA. Many of these …