Numerous preclinical studies support the role of spinal neuroimmune activation in the
pathogenesis of chronic pain, and targeting glia (eg, microglia/astrocyte)-or macrophage …

Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-
surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains …

While spinal microglia play a role in early stages of neuropathic pain etiology, whether they
are useful targets to reverse chronic pain at late stages remains unknown. Here, we show …

We recently showed that patients with different chronic pain conditions (such as chronic low
back pain, fibromyalgia, migraine and Gulf War illness) demonstrated elevated brain and/or …

Chronic pain is a prevalent and debilitating condition, conveying immense human burden.
Suffering is caused not only by painful symptoms, but also through psychopathological and …

Recent evidence implicates an adaptive immune response in the central nervous system
(CNS) mechanisms of neuropathic pain. This review identifies how neuropathic pain alters …

The nociceptive nervous system and the immune system serve to defend and alarm the host
of imminent or actual damage. However, persistent or recurring exposure of neurons to …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Current deficiency in our understanding of acute-to-chronic pain transition remains a hurdle
for developing effective treatments against chronic pain. Whereas neurocentric mechanisms …

Neuropathic pain represents a major problem in clinical medicine because it causes
debilitating suffering and is largely resistant to currently available analgesics. A …