[HTML][HTML] Synthesis and Biological Evaluation of Chalconesulfonamides: En Route to Proapoptotic Agents with Antiestrogenic Potency
SK Krymov, DI Salnikova, LG Dezhenkova… - Pharmaceuticals, 2023 - mdpi.com
Breast and other estrogen receptor α-positive cancers tend to develop resistance to existing
drugs. Chalcone derivatives possess anticancer activity based on their ability to form …
drugs. Chalcone derivatives possess anticancer activity based on their ability to form …
Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells
MB Dos Santos, D Bertholin Anselmo… - Journal of enzyme …, 2019 - Taylor & Francis
Chalcones are valuable structures for drug discovery due to their broad bioactivity spectrum.
In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast …
In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast …
[HTML][HTML] Cytotoxic effects on breast cancer cell lines of chalcones derived from a natural precursor and their molecular docking analysis
L Bustos, C Echiburú-Chau, A Castro-Alvarez… - Molecules, 2022 - mdpi.com
This study aimed to determine the in vitro cytotoxicity and understand possible cytotoxic
mechanisms via an in silico study of eleven chalcones synthesized from two …
mechanisms via an in silico study of eleven chalcones synthesized from two …
Synthesis, in-vitro screening, and docking analysis of novel pyrrolidine and piperidine-substituted ethoxy chalcone as anticancer agents
A series of novel-substituted chalcone analogs were synthesized and evaluated for
antiproliferative activity against estrogen receptor-positive MCF-7 breast cancer cell lines …
antiproliferative activity against estrogen receptor-positive MCF-7 breast cancer cell lines …
[HTML][HTML] Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis
MIM Darwish, AM Moustafa, AM Youssef, M Mansour… - Molecules, 2023 - mdpi.com
Chalcones are interesting anticancer drug candidates which have attracted much interest
due to their unique structure and their extensive biological activity. Various functional …
due to their unique structure and their extensive biological activity. Various functional …
New Chalcone Ester Derivatives as Potential Cytotoxic Agents
R Binda da Silva… - Chemistry & … - Wiley Online Library
Chalcones are a group with recognized biological potential against many diseases,
including cancer. Thus, studies on these structure have become an attractive chemical …
including cancer. Thus, studies on these structure have become an attractive chemical …
Chalcones: potential chemotherapeutic compounds and educational tools for closing the loop in STEM
AE Russell, BR Gines - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus The study discussed herein describes the synthesis of halogenated chalcones
as potential chemotherapeutics. The synthesis work was conducted by undergraduate …
as potential chemotherapeutics. The synthesis work was conducted by undergraduate …
Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: synthesis, characterization and anticancer activity
Cancer treatment still requires new compounds to be discovered. Chalcone and its
derivatives exhibit anticancer potential in different cancer cells. A new series of benzofuran …
derivatives exhibit anticancer potential in different cancer cells. A new series of benzofuran …
Design, synthesis, characterization and cytotoxic activity of new ortho-hydroxy and indole-chalcone derivatives against breast cancer cells (MCF-7)
M Jumaah, M Khairuddean, SJ Owaid… - Medicinal Chemistry …, 2022 - Springer
Twenty-seven new ortho-hydroxy chalcone and a series of indole-chalcone derivatives have
been designed and synthesized. The structures of all newly-synthesized compounds were …
been designed and synthesized. The structures of all newly-synthesized compounds were …
[HTML][HTML] Synthesis and Antiproliferative Effect of 3, 4, 5-Trimethoxylated Chalcones on Colorectal and Prostatic Cancer Cells
C Letulle, FX Toublet, A Pinon, S Hba, A Laurent… - Pharmaceuticals, 2024 - mdpi.com
In the context of designing innovative anticancer agents, the synthesis of a series of
chalcones bearing a 3, 4, 5-trimethoxylated A ring and a variety of B rings, including phenols …
chalcones bearing a 3, 4, 5-trimethoxylated A ring and a variety of B rings, including phenols …