It has previously been reported that, in periodontitis lesions, T cells with a memory/activated
phenotype and with a type 2 cytokine profile accumulate in an oligoclonal fashion …

Background: Cytokines play an important rôle in controlling inflammatory processes and
tissue homeostasis. Periodontitis, as any other chronic inflammatory disease, results from a …

It has been suggested that the types of inflammatory round cell infiltrates and the divergence
in the cytokine production profile by macrophages and helper T cells regulate the course of …

Chronic inflammation induced by bacteria often leads to host-mediated destruction of tissues
adjacent to the sites of microbial insult. The chronic inflammatory process of adult …

Expression of mRNA for IL–α, IL‐1β, IL‐2, IL‐4, IL‐5, IL‐6 and TNF‐α in inflamed gingiva
was quantitatively examined by ribonuclease protection assay and in situ hybridization. The …

Periodontitis is a chronic inflammatory disease of the soft and hard supporting tissues of the
teeth and is a major cause of tooth loss in adults. The local host response to …

An accumulation of elevated numbers of macrophages (Mø) and Ig producing cells is
associated with localized and chronically inflamed gingiva of patients with adult …

Adult periodontitis is a chronic destructive disease characterized by an interaction between
gram‐negative bacteria and the host inflammatory response. Microbial substances such as …

Background: Both the virulence factors of periodontopathic bacteria and the immune
response against them have been involved in tissue destruction observed in periodontal …

Numerous studies have attempted to elucidate the cytokine networks involved in chronic
periodontitis, often with conflicting results. A variety of techniques were used to study cells in …