Differential genome analyses of metabolic enzymes in Pseudomonas aeruginosa for drug target identification
D Perumal, CS Lim, KR Sakharkar… - In silico …, 2007 - content.iospress.com
Complete genome sequences of several pathogenic bacteria have been determined, and
many more such projects are currently under way. While these data potentially contain all …
many more such projects are currently under way. While these data potentially contain all …
A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa
KR Sakharkar, MK Sakharkar, VTK Chow - In silico biology, 2004 - content.iospress.com
Complete genome sequences of several pathogenic bacteria have been determined, and
many more such projects are currently under way. While these data potentially contain all …
many more such projects are currently under way. While these data potentially contain all …
Bacterial genomics: potential for antimicrobial drug discovery
B Fritz, GA Raczniak - BioDrugs, 2002 - Springer
The sequencing of entire bacterial genomes is becoming increasingly routine, promising to
revolutionise approaches to identifying putative antimicrobial drug targets. In silico methods …
revolutionise approaches to identifying putative antimicrobial drug targets. In silico methods …
METABOLIC PATHWAY ANALYSIS OF S. PNEUMONIAE: AN IN SILICO APPROACH TOWARDS DRUG-DESIGN
S Singh, BK Malik, DK Sharma - Journal of bioinformatics and …, 2007 - World Scientific
The emergence of multidrug resistant varieties of Streptococcus pneumoniae (S.
pneumoniae) has led to a search for novel drug targets. An in silico comparative analysis of …
pneumoniae) has led to a search for novel drug targets. An in silico comparative analysis of …
Biocomputational strategies for microbial drug target identification
KR Sakharkar, MK Sakharkar, VTK Chow - New antibiotic targets, 2008 - Springer
The complete genome sequences of about 300 bacteria (mostly pathogenic) have been
determined, and many more such projects are currently in progress. The detection of …
determined, and many more such projects are currently in progress. The detection of …
In silico identification of putative drug targets from different metabolic pathways of Aeromonas hydrophila
V Sharma, P Gupta, A Dixit - In silico biology, 2008 - content.iospress.com
Aeromonas hydrophila is a major pathogen both of aquatic and terrestrial organisms,
including humans. Infection with A. hydrophila results in severe economic losses to the …
including humans. Infection with A. hydrophila results in severe economic losses to the …
[HTML][HTML] Computational genome analyses of metabolic enzymes in Mycobacterium leprae for drug target identification
A Shanmugam, J Natarajan - Bioinformation, 2010 - ncbi.nlm.nih.gov
Leprosy is an infectious disease caused by Mycobacterium leprae. M. leprae has undergone
a major reductive evolution leaving a minimal set of functional genes for survival. It remains …
a major reductive evolution leaving a minimal set of functional genes for survival. It remains …
Genome Mining of Pseudomonas Species: Diversity and Evolution of Metabolic and Biosynthetic Potential
Microbial genome sequencing has uncovered a myriad of natural products (NPs) that have
yet to be explored. Bacteria in the genus Pseudomonas serve as pathogens, plant growth …
yet to be explored. Bacteria in the genus Pseudomonas serve as pathogens, plant growth …
PseudoCyc, A Pathway-Genome Database for Pseudomonas aeruginosa
A pathway-genome database (PGDB) describes the entire genome of an organism, as well
as its biochemical pathways, reactions, and enzymes. Our PathoLogic software can …
as its biochemical pathways, reactions, and enzymes. Our PathoLogic software can …
Novel computational methods in anti-microbial target identification
C Freiberg - Drug Discovery Today, 2001 - Elsevier
The large number of microbial genome sequences currently available facilitates completely
new methods of cross-genome analyses, which aid in target identification and prioritization …
new methods of cross-genome analyses, which aid in target identification and prioritization …
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