[HTML][HTML] Rapid and long-lasting antidepressant-like effects of ketamine and their relationship with the expression of brain enzymes, BDNF, and astrocytes
GSB Viana, EM Do Vale, ARA de Araujo… - Brazilian Journal of …, 2020 - SciELO Brasil
Ketamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting
antidepressant effects, but how the drug shows its sustained effects is still a matter of …
antidepressant effects, but how the drug shows its sustained effects is still a matter of …
Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus
LSB Garcia, CM Comim, SS Valvassori… - Progress in neuro …, 2008 - Elsevier
Ketamine is a non-competitive antagonist to the phencyclidine site of N-methyl-d-aspartate
(NMDA) receptor. Clinical findings point to a rapid onset of action for ketamine on the …
(NMDA) receptor. Clinical findings point to a rapid onset of action for ketamine on the …
[HTML][HTML] The monoaminergic pathways and inhibition of monoamine transporters interfere with the antidepressive-like behavior of ketamine
GS de Barros Viana, CC Xavier, EM do Vale… - IBRO reports, 2018 - Elsevier
Ketamine (KET), a NMDA receptor antagonist, has been studied for its rapid and efficacious
antidepressant effect, even for the treatment-resistant depression. Although depression is a …
antidepressant effect, even for the treatment-resistant depression. Although depression is a …
Effects of ketamine administration on the phosphorylation levels of CREB and TrKB and on oxidative damage after infusion of MEK inhibitor
Background Ketamine, an antagonist of N-methyl-d-aspartate (NMDA) receptors, has
presented antidepressant effects in basic and clinical studies. The MAPK kinase (MEK) …
presented antidepressant effects in basic and clinical studies. The MAPK kinase (MEK) …
Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies
TH Pham, AM Gardier - Pharmacology & therapeutics, 2019 - Elsevier
Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor, displays
a fast antidepressant activity in treatment-resistant depression and in rodent models of …
a fast antidepressant activity in treatment-resistant depression and in rodent models of …
Chronic administration of ketamine elicits antidepressant‐like effects in rats without affecting hippocampal brain‐derived neurotrophic factor protein levels
LS Garcia, CM Comim, SS Valvassori… - Basic & clinical …, 2008 - Wiley Online Library
A growing body of evidence has pointed to the blockade of the N‐methyl‐d‐aspartate
(NMDA) receptor signaling as a potential therapeutic target for the treatment of major …
(NMDA) receptor signaling as a potential therapeutic target for the treatment of major …
Antidepressant-like effects of low ketamine dose is associated with increased hippocampal AMPA/NMDA receptor density ratio in female Wistar–Kyoto rats
Y Tizabi, BH Bhatti, KF Manaye, JR Das, L Akinfiresoye - Neuroscience, 2012 - Elsevier
Preclinical as well as limited clinical studies indicate that ketamine, a non-competitive
glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, may exert a quick and …
glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, may exert a quick and …
[HTML][HTML] Effect of acute administration of ketamine and imipramine on creatine kinase activity in the brain of rats
OBJECTIVE: Clinical findings suggest that ketamine may be used for the treatment of major
depression. The present study aimed to compare behavioral effects and brain Creatine …
depression. The present study aimed to compare behavioral effects and brain Creatine …
Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine
S Deyama, K Kaneda - Neuropharmacology, 2023 - Elsevier
The neurotrophic hypothesis of depression proposes that reduced levels of brain-derived
neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) contribute to …
neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) contribute to …
Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine
Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …