Anti-infectives clinical progress of HIV-1 integrase inhibitors
LQ Al-Mawsawi, RI Al-Safi… - Expert opinion on …, 2008 - Taylor & Francis
Background: HIV-1 integrase (IN) represents a therapeutically advantageous viral target to
treat HIV/AIDS in the clinic. Over a decade of progress in the field has resulted in IN inhibitor …
treat HIV/AIDS in the clinic. Over a decade of progress in the field has resulted in IN inhibitor …
HIV‐1 integrase inhibitors: 2005–2006 update
Abstract HIV‐1 integrase (IN) catalyzes the integration of proviral DNA into the host genome,
an essential step for viral replication. Inhibition of IN catalytic activity provides an attractive …
an essential step for viral replication. Inhibition of IN catalytic activity provides an attractive …
HIV integrase inhibitors
MA Walker, TD Johnson, OK Kim, Y Zhang - US Patent 6,548,546, 2003 - Google Patents
BACKGROUND Human immunodeficiency virus (HIV) has been identi fied as the etiological
agent responsible for acquired immune deficiency Syndrome (AIDS), a fatal disease …
agent responsible for acquired immune deficiency Syndrome (AIDS), a fatal disease …
Update on HIV integrase inhibitors for the treatment of HIV-1 infection
B Max - Future Virology, 2019 - Taylor & Francis
It has been over 30 years since the first antiretroviral agent was approved for treatment of
HIV-1 infection and its impact on morbidity and mortality has been dramatic. However, early …
HIV-1 infection and its impact on morbidity and mortality has been dramatic. However, early …
Advances in the development of HIV integrase strand transfer inhibitors
Y Wang, SX Gu, Q He, R Fan - European Journal of Medicinal Chemistry, 2021 - Elsevier
Abstract HIV-1 integrase (IN) is a key enzyme in viral replication that catalyzes the covalent
integration of viral cDNA into the host genome. Currently, five HIV-1 IN strand transfer …
integration of viral cDNA into the host genome. Currently, five HIV-1 IN strand transfer …
The future of integrase inhibitors of HIV-1
I Malet, V Calvez, AG Marcelin - Current opinion in virology, 2012 - Elsevier
Integration of the HIV-1 DNA is required and essential to maintain the viral DNA in the
infected cell. Integration process occurs in several events, mainly endonucleolytic …
infected cell. Integration process occurs in several events, mainly endonucleolytic …
Authentic HIV-1 integrase inhibitors
C Liao, C Marchand, TR Burke Jr… - Future medicinal …, 2010 - Taylor & Francis
HIV-1 integrase (IN) is indispensable for HIV-1 replication and has become a validated
target for developing anti-AIDS agents. In two decades of development of IN inhibition …
target for developing anti-AIDS agents. In two decades of development of IN inhibition …
HIV-1 integrase inhibitors: an emerging clinical reality
R Dayam, LQ Al-Mawsawi, N Neamati - Drugs in R & D, 2007 - Springer
From the discovery of HIV-1 integrase (IN) inhibitors using enzyme-based assays in 1992, it
has taken 15 years to achieve success in human clinical trials. Currently available …
has taken 15 years to achieve success in human clinical trials. Currently available …
Novel integrase inhibitors for HIV
N Prada, M Markowitz - Expert Opinion on Investigational Drugs, 2010 - Taylor & Francis
Importance of the field: Integrase inhibitors are the newest class of antiretroviral agents
developed to treat HIV-1 infection. Raltegravir (RAL), the only integrase inhibitor (INI) …
developed to treat HIV-1 infection. Raltegravir (RAL), the only integrase inhibitor (INI) …
Role of integrase inhibitors in the treatment of HIV disease
L Palmisano - Expert review of anti-infective therapy, 2007 - Taylor & Francis
The introduction of highly active antiretroviral therapy (HAART) has produced a dramatic
reduction in HIV-related mortality and morbidity among populations with widespread access …
reduction in HIV-related mortality and morbidity among populations with widespread access …