Metabolomics and its potential in drug development
Metabolomics is the global and unbiased survey of the complement of small molecules
(say,< 1kDa) in a biofluid, tissue, organ or organism and measures the end-products of the …
(say,< 1kDa) in a biofluid, tissue, organ or organism and measures the end-products of the …
Metabolomics and biochemical profiling in drug discovery and development.
SM Watkins, JB German - Current opinion in molecular therapeutics, 2002 - europepmc.org
Metabolomics brings a different and complementary perspective to biomedical research and
therapeutic development. Metabolites are measurable, directly responsible for health, and …
therapeutic development. Metabolites are measurable, directly responsible for health, and …
Metabolomics in drug discovery and development
DG Robertson, U Frevert - Clinical Pharmacology & …, 2013 - Wiley Online Library
Metabolomics technology is being utilized across the spectrum of drug discovery and
development; from the assessment of unanticipated biochemical sequelae of target …
development; from the assessment of unanticipated biochemical sequelae of target …
Metabolomics and personalized medicine
N Koen, I Du Preez - Advances in protein chemistry and structural biology, 2016 - Elsevier
Current clinical practice strongly relies on the prognosis, diagnosis, and treatment of
diseases using methods determined and averaged for the specific diseased …
diseases using methods determined and averaged for the specific diseased …
Practical metabolomics in drug discovery
KM Wilcoxen, T Uehara, KT Myint, Y Sato… - Expert opinion on drug …, 2010 - Taylor & Francis
Importance of the field: Metabolomics is increasingly becoming an important field in the
pharmaceutical industry to support the discovery and development of therapeutic agents. It …
pharmaceutical industry to support the discovery and development of therapeutic agents. It …
Metabolomics and biomarkers for drug discovery
PK Yeung - Metabolites, 2018 - mdpi.com
Metabolomics and biomarkers are increasingly used in drug discovery and development,
and are applied to personalized medicine. Progress in these research areas has increased …
and are applied to personalized medicine. Progress in these research areas has increased …
Exploration of individuality in drug metabolism by high-throughput metabolomics: the fast line for personalized medicine
O Trifonova, RA Knight, A Lisitsa, G Melino… - Drug Discovery …, 2016 - Elsevier
Highlights•Individuality in drug metabolism can be a reliable biomarker of drug
efficacy/safety.•At present, only genetic tests are used to predict individuality in drug …
efficacy/safety.•At present, only genetic tests are used to predict individuality in drug …
Metabolomics as a challenging approach for medicinal chemistry and personalized medicine
“Omics” sciences have been developed to provide a holistic point of view of biology and to
better understand the complexity of an organism as a whole. These systems biology …
better understand the complexity of an organism as a whole. These systems biology …
Applications of metabolomics in drug discovery and development
DS Wishart - Drugs in R & D, 2008 - Springer
Metabolomics is a relatively new field of 'omics' technology that is primarily concerned with
the global or system-wide characterization of small molecule metabolites using technologies …
the global or system-wide characterization of small molecule metabolites using technologies …
Metabolomics
Metabolomics is a recently developed technique for the analysis of the small-molecule
component of biological systems and samples. Metabolites consist of a very heterogeneous …
component of biological systems and samples. Metabolites consist of a very heterogeneous …