Clostridium difficile Whole Genome Sequencing Reveals Limited Transmission Among Symptomatic Children: A Single-Center Analysis

LK Kociolek, DN Gerding, RO Espinosa… - Clinical infectious …, 2018 - academic.oup.com
Abstract Background Although pediatric Clostridium difficile infections (CDIs) are increasing,
C. difficile transmission patterns among children are poorly understood. Methods We …

Molecular epidemiology of Clostridium difficile infections in children: a retrospective cohort study

LK Kociolek, SJ Patel, ST Shulman… - infection control & …, 2015 - cambridge.org
OBJECTIVEThe molecular epidemiology of pediatric Clostridium difficile infection (CDI) is
poorly understood. We aimed to identify the restriction endonuclease analysis (REA) groups …

Molecular Epidemiology and Genetic Relatedness of Clostridioides difficile Isolates in Pediatric Oncology and Transplant Patients Using Whole Genome Sequencing

R Barbar, JN Brazelton, KC Carroll… - Clinical Infectious …, 2023 - academic.oup.com
Abstract Background The incidence of Clostridioides difficile infection (CDI) has been rising
among hospitalized children, with poor understanding of genomic variability of C. difficile …

Patient and Strain Characteristics Associated With Clostridium difficile Transmission and Adverse Outcomes

JSH Martin, DW Eyre, WN Fawley… - Clinical Infectious …, 2018 - academic.oup.com
Background No study has used whole-genome sequencing (WGS) to investigate risk factors
for Clostridium difficile (CD) transmission between cases, or assessed the impact of recent …

Clinical and Microbiological Characteristics of Clostridium difficile Infection Among Hospitalized Children in the Netherlands

SM van Dorp, E Smajlović, CW Knetsch… - Clinical Infectious …, 2017 - academic.oup.com
Background. Little is known about pediatric Clostridium difficile infection (CDI) epidemiology.
We describe the clinical and microbiological characteristics of CDI among hospitalized …

Clostridium difficile: Investigating Transmission Patterns Between Infected and Colonized Patients Using Whole Genome Sequencing

LY Kong, DW Eyre, J Corbeil… - Clinical Infectious …, 2019 - academic.oup.com
Background Whole genome sequencing (WGS) studies can enhance our understanding of
the role of patients with asymptomatic Clostridium difficile colonization in transmission …

Clostridium difficile Infection Among Children Across Diverse US Geographic Locations

JM Wendt, JA Cohen, Y Mu, GK Dumyati, JR Dunn… - …, 2014 - publications.aap.org
OBJECTIVE: Little is known about the epidemiology of Clostridium difficile infection (CDI)
among children, particularly children≤ 3 years of age in whom colonization is common but …

Whole-genome analysis reveals the evolution and transmission of an MDR DH/NAP11/106 Clostridium difficile clone in a paediatric hospital

LK Kociolek, EA Ozer, DN Gerding… - Journal of …, 2018 - academic.oup.com
Background Clostridium difficile strain DH/NAP11/106, a relatively antibiotic-susceptible
strain, is now the most common cause of C. difficile infection (CDI) among adults in the USA …

Whole‐genome sequencing links Clostridium (Clostridioides) difficile in a single hospital to diverse environmental sources in the community

SC Lim, DA Collins, K Imwattana… - Journal of applied …, 2022 - academic.oup.com
Abstract Aims To investigate if Clostridium (Clostridioides) difficile infection (CDI),
traditionally thought of as hospital‐acquired, can be genomically linked to hospital or …

Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing

DW Eyre, ML Cule, DJ Wilson, D Griffiths… - … England Journal of …, 2013 - Mass Medical Soc
Background It has been thought that Clostridium difficile infection is transmitted
predominantly within health care settings. However, endemic spread has hampered …