The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility
PJ Castaldi, MH Cho, AA Litonjua, P Bakke… - American journal of …, 2011 - atsjournals.org
Two recent metaanalyses of genome-wide association studies conducted by the CHARGE
and SpiroMeta consortia identified novel loci yielding evidence of association at or near …
and SpiroMeta consortia identified novel loci yielding evidence of association at or near …
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease
Rationale: A genome-wide association study (GWAS) for circulating chronic obstructive
pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker …
pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker …
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
Background Pulmonary function decline is a major contributor to morbidity and mortality
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function
M Soler Artigas, LV Wain, E Repapi… - American journal of …, 2011 - atsjournals.org
Rationale: Genomic loci are associated with FEV1 or the ratio of FEV1 to FVC in population
samples, but their association with chronic obstructive pulmonary disease (COPD) has not …
samples, but their association with chronic obstructive pulmonary disease (COPD) has not …
A genome-wide association study in Hispanics/Latinos identifies novel signals for lung function. The Hispanic Community Health Study/Study of Latinos
Rationale: Lung function and chronic obstructive pulmonary disease (COPD) are heritable
traits. Genome-wide association studies (GWAS) have identified numerous pulmonary …
traits. Genome-wide association studies (GWAS) have identified numerous pulmonary …
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a common, complex disease associated
with substantial morbidity and mortality. COPD is defined by irreversible airflow obstruction; …
with substantial morbidity and mortality. COPD is defined by irreversible airflow obstruction; …
Framingham Heart Study genome-wide association: results for pulmonary function measures
Background Pulmonary function measures obtained by spirometry are used to diagnose
chronic obstructive pulmonary disease (COPD) and are highly heritable. We conducted …
chronic obstructive pulmonary disease (COPD) and are highly heritable. We conducted …
Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease
Rationale: Genome-wide association studies have shown significant associations between
variants near hedgehog interacting protein HHIP, FAM13A, and cholinergic nicotinic …
variants near hedgehog interacting protein HHIP, FAM13A, and cholinergic nicotinic …
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13
The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely
unknown. To date, genome-wide association studies (GWASs) of limited size have identified …
unknown. To date, genome-wide association studies (GWASs) of limited size have identified …
Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers
Rationale: Previous studies of chronic obstructive pulmonary disease (COPD) have
suggested that genetic factors play an important role in the development of disease …
suggested that genetic factors play an important role in the development of disease …