Susceptibility to endosomal degradation is a decisive contribution to a protein's
immunogenicity. It is assumed that the processing kinetics of structured proteins are …

Proteolytic susceptibility during endolysosomal degradation is decisive for allergic
sensitization. In the major birch pollen allergen Bet v 1 most protease cleavage sites are …

We use state-of-the-art NMR experiments to measure apparent p K a values in the native
protein environment and employ a cutting-edge combination of enhanced sampling and …

Introduction: Understanding, which factors determine the immunogenicity and immune
polarizing properties of proteins, is an important prerequisite for designing better vaccines …

Phl p 5, a 29 kDa major allergen from timothy grass pollen, is one of the most reactive
members of group 5 allergens. Its sequence comprises two repeats of a novel alanine-rich …

Background The search for intrinsic factors, which account for a protein's capability to act as
an allergen, is ongoing. Fold stability has been identified as a molecular feature that affects …

We present an analysis of the folding behavior of the 159-residue major birch pollen
allergen Bet v 1. The protein contains a water-filled channel running through it …

The precise structural characterization of allergens is a basic requirement to improve
diagnostics and to find therapeutic strategies against allergic disorders. Natural grass pollen …

The family of profilin allergens is a common class of proteins found in plants, viruses and
various eukaryotes including mammals. Profilins are characterized by an evolutionary …

Abstract Par j 2.0101, a major allergen of the Parietaria judaica pollen, was expressed in E.
coli, purified to homogeneity and fully characterised both at the structural and the functional …