[PDF][PDF] Cell-based drug delivery devices using phagocytosis-resistant backpacks

MF Rubner, S Mitragotri - Adv Mater, 2011 - academia.edu
Macrophages, ubiquitous phagocytic cells in the human immune system, play a key role in
homeostatic, immunological, and inflammatory processes.[1–2] Macrophages are widely …

Recent advances in macrophage-mediated drug delivery systems

T Liang, R Zhang, X Liu, Q Ding, S Wu… - International journal …, 2021 - Taylor & Francis
Macrophages have been extensively used in the development of drug delivery systems, as
they can prolong the circulation and release of drugs, extend their half-life, increase their …

Cellular backpacks for macrophage immunotherapy

CW Shields IV, MA Evans, LLW Wang, N Baugh… - Science …, 2020 - science.org
Adoptive cell transfers have emerged as a disruptive approach to treat disease in a manner
that is more specific than using small-molecule drugs; however, unlike traditional drugs …

Macrophage cell membrane‐cloaked nanoplatforms for biomedical applications

J Lopes, D Lopes, M Pereira‐Silva, D Peixoto… - Small …, 2022 - Wiley Online Library
Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage
nanoparticles to circumvent some limitations of nanoscale materials. This emergent cell …

Monocyte-mediated delivery of polymeric backpacks to inflamed tissues: a generalized strategy to deliver drugs to treat inflammation

AC Anselmo, JB Gilbert, S Kumar, V Gupta… - Journal of Controlled …, 2015 - Elsevier
Targeted delivery of drugs and imaging agents to inflamed tissues, as in the cases of cancer,
Alzheimer's disease, Parkinson's disease, and arthritis, represents one of the major …

Advancements in macrophage-targeted drug delivery for effective disease management

H Liu, H Lv, X Duan, Y Du, Y Tang… - International Journal of …, 2023 - Taylor & Francis
Macrophages play a crucial role in tissue homeostasis and the innate immune system. They
perform essential functions such as presenting antigens, regulating cytokines, and …

Nanoparticle‐laden macrophages for tumor‐tropic drug delivery

W Zhang, M Wang, W Tang, R Wen, S Zhou… - Advanced …, 2018 - Wiley Online Library
Macrophages hold great potential in cancer drug delivery because they can sense
chemotactic cues and home to tumors with high efficiency. However, it remains a challenge …

Neutrophils enable local and non‐invasive liposome delivery to inflamed skeletal muscle and ischemic heart

J Che, A Najer, AK Blakney, PF McKay… - Advanced …, 2020 - Wiley Online Library
Uncontrolled inflammation is a major pathological factor underlying a range of diseases
including autoimmune conditions, cardiovascular disease, and cancer. Improving localized …

Living leukocyte‐based drug delivery systems

Y Chen, D Qin, J Zou, X Li, XD Guo, Y Tang… - Advanced …, 2023 - Wiley Online Library
Leukocytes play a vital role in immune responses, including defending against invasive
pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the …

Targeted drug delivery to macrophages

NK Jain, V Mishra, NK Mehra - Expert opinion on drug delivery, 2013 - Taylor & Francis
Introduction: Targeted drug delivery to the macrophages appears to be an attractive
proposition to improve therapeutic efficacy of enclosed drug. Thus, macrophages can be …