Kidney dysfunction and cadmium exposure–factors influencing dose–response relationships

G Nordberg, T Jin, X Wu, J Lu, L Chen, Y Liang… - Journal of Trace …, 2012 - Elsevier
Our early toxicological studies showed that metallothionein (MT) is a protein that carries
cadmium (Cd) to the kidney, explaining why Cd exposures during long time periods may …

Prevalence of kidney dysfunction in humans–relationship to cadmium dose, metallothionein, immunological and metabolic factors

GF Nordberg, T Jin, X Wu, J Lu, L Chen, L Lei, F Hong… - Biochimie, 2009 - Elsevier
Long term cadmium (Cd) exposure in occupational and general environments may give rise
to kidney dysfunction. This effect is usually considered to be the critical effect, ie the effect …

Critical exposure level of cadmium for elevated urinary metallothionein—an occupational population study in China

L Chen, T Jin, B Huang, G Nordberg… - Toxicology and applied …, 2006 - Elsevier
Cadmium is a well-known nephrotoxic agent with extremely long biological half-time of 15–
30 years in humans. To prevent nephrotoxicity induced by cadmium, it is necessary to …

[HTML][HTML] A polymorphism in metallothionein 1A (MT1A) is associated with cadmium-related excretion of urinary beta 2‐microglobulin

L Lei, X Chang, G Rentschler, L Tian, G Zhu… - Toxicology and applied …, 2012 - Elsevier
OBJECTIVES: Cadmium (Cd) toxicity of the kidney varies between individuals despite
similar exposure levels. In humans Cd is mainly bound to metallothioneins (MT), which …

The association between renal tubular dysfunction and zinc level in a Chinese population environmentally exposed to cadmium

X Chen, Z Wang, G Zhu, GF Nordberg, X Ding… - Biological Trace Element …, 2018 - Springer
Studies in vivo and in vitro have shown a protective effect of zinc against renal dysfunction
caused by cadmium exposure. However, limited human data is available. In this study, we …

Cadmium and human health: a perspective based on recent studies in China

G Nordberg - The Journal of Trace Elements in Experimental …, 2003 - Wiley Online Library
Cadmium (Cd) occurs in low concentrations in all human diets and in cigarettes. In
contaminated areas and in certain occupations, high human exposures occur. In assessing …

Historical perspectives on cadmium toxicology

GF Nordberg - Toxicology and applied pharmacology, 2009 - Elsevier
The first health effects of cadmium (Cd) were reported already in 1858. Respiratory and
gastrointestinal symptoms occurred among persons using Cd-containing polishing agent …

Excretion of urinary cadmium, copper, and zinc in cadmium-exposed and nonexposed subjects, with special reference to urinary excretion of β2-microglobulin and …

M Nakajima, E Kobayashi, Y Suwazono… - Biological trace element …, 2005 - Springer
The objectives of this study were to examine the association between urinary excretion of
cadmium (U-Cd) copper (U-Cu), and zinc (U-Zn) and the severity of two different indicators …

Plasma metallothionein antibody and cadmium-induced renal dysfunction in an occupational population in China

L Chen, T Jin, B Huang, X Chang, L Lei… - Toxicological …, 2006 - academic.oup.com
It has been reported that anti-metallothionein (a metallothionein antibody) is present in the
circulation of healthy subjects and in patients suffering from atopic dermatitis. The aim of this …

The risk factors of blood cadmium elevation in chronic kidney disease

KF Tsai, PC Hsu, CT Kung, CT Lee, HL You… - International Journal of …, 2021 - mdpi.com
Low-level cadmium exposure has adverse effects on chronic kidney disease (CKD);
however, the risk factors for elevated blood cadmium levels (BCLs) have not been studied in …