CC-chemokine receptor 6 and its ligand macrophage inflammatory protein 3α might be involved in the amplification of local necroinflammatory response in the liver

Y Shimizu, H Murata, Y Kashii, K Hirano, H Kunitani… - Hepatology, 2001 - Elsevier
It is not fully understood how antigen-specific or-nonspecific T cells migrate into the liver in
various liver diseases. Macrophage inflammatory protein (MIP)-3α is a chemokine that is …

[PDF][PDF] Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C‐C motif chemokine receptor 8 in mice

F Heymann, L Hammerich, D Storch, M Bartneck… - …, 2012 - Wiley Online Library
Chemokines critically control the infiltration of immune cells upon liver injury, thereby
promoting hepatic inflammation and fibrosis. The chemokine receptor CCR8 can affect …

[PDF][PDF] C‐C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice

P Chu, N Nakamoto, H Ebinuma, S Usui, K Saeki… - …, 2013 - Wiley Online Library
Chemokine receptors mediate migration of immune cells into the liver, thereby promoting
liver inflammation. C‐C motif chemokine receptor (CCR) 9+ macrophages are crucial in the …

Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis

L Hammerich, JM Bangen, O Govaere… - Hepatology, 2014 - journals.lww.com
Chronic liver injury promotes hepatic inflammation, representing a prerequisite for organ
fibrosis. We hypothesized a contribution of chemokine receptor CCR6 and its ligand …

[HTML][HTML] Functional roles of CCL5/RANTES in liver disease

L Chen, Q Zhang, C Yu, F Wang, X Kong - Liver Research, 2020 - Elsevier
Inflammation, which is mediated by leukocyte trafficking and activation, plays a prominent
role in the pathogenesis of acute and chronic liver injury. Chemokines are critical mediators …

CC chemokine ligand 2/monocyte chemoattractant protein-1 directly inhibits NKT cell IL-4 production and is hepatoprotective in T cell-mediated hepatitis in the mouse

MN Ajuebor, CM Hogaboam, T Le… - The Journal of …, 2003 - journals.aai.org
T cell-mediated liver diseases are associated with elevated serum levels of CC chemokine
ligand 2 (CCL2)/monocyte chemoattractant protein-1 (MCP-1). However, the extent to which …

[HTML][HTML] Chemokine receptor Ccr6 deficiency alters hepatic inflammatory cell recruitment and promotes liver inflammation and fibrosis

S Affò, D Rodrigo-Torres, D Blaya, O Morales-Ibanez… - PLoS …, 2015 - journals.plos.org
Chronic liver diseases are characterized by a sustained inflammatory response in which
chemokines and chemokine-receptors orchestrate inflammatory cell recruitment. In this …

CCR5 in T cell-mediated liver diseases: what's going on?

MN Ajuebor, JA Carey, MG Swain - The Journal of Immunology, 2006 - journals.aai.org
The chemokine receptor CCR5 came into worldwide prominence a decade ago when it was
identified as one of the major coreceptors for HIV infectivity. However, subsequent studies …

[PDF][PDF] CCR5 deficiency exacerbates T‐cell–mediated hepatitis in mice

C Moreno, T Gustot, C Nicaise, E Quertinmont… - …, 2005 - Wiley Online Library
Experimental T‐cell–mediated hepatitis induced by concanavalin A (Con A) involves the
production of different cytokines and chemokines and is characterized by leukocyte …

CCL3/MIP‐1α is pro‐inflammatory in murine T cell‐mediated hepatitis by recruiting CCR1‐expressing CD4+ T cells to the liver

MN Ajuebor, CM Hogaboam, T Le… - European journal of …, 2004 - Wiley Online Library
T cell‐mediated hepatitis is associated with significant morbidity and mortality worldwide.
Levels of C‐C chemokine ligand 3/macrophage inflammatory protein‐1α (CCL3/MIP‐1α) are …