Like many other complex biological phenomena, pain is starting to be studied at the level of
the gene. Advances in molecular biological technology have allowed the cloning, mapping …

Noxious stimuli usually cause pain and pain usually arises from noxious stimuli, but
exceptions to these apparent truisms are the basis for clinically important problems and …

Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of
inflammation. Although the mechanism underlying thermal hyperalgesia is well understood …

Nociception provides a means of neural feedback that allows the central nervous system
(CNS) to detect and avoid noxious and potentially damaging stimuli in both active and …

There are many known risk factors for chronic pain conditions, yet the biological
underpinnings that link these factors to abnormal processing of painful signals are only just …

Pain exists as both a sensory event of the peripheral and central nervous systems and as a
profound phenomenological experience that affects the processes of consciousness and …

Acute mechanical, thermal, and chemically induced pains in the skin are signalled by a set
of specific nociceptive afferents, which encode the magnitude of the perceived pain by their …

Pain, which afflicts up to 20% of the population at any time, provides both a massive
therapeutic challenge and a route to understanding mechanisms in the nervous system …

To paraphrase Cole Porter's famous 1926 song,“What is this thing called pain? This funny
thing called pain, just who can solve its mystery?” Pain, like love, is all consuming: when you …

Pain is a major symptom of many different diseases. Modern pain research has uncovered
important neuronal mechanisms that are underlying clinically relevant pain states, and …