Discovery of natural alkaloids as potent and selective inhibitors against human carboxylesterase 2
YS Zhao, XK Qian, XQ Guan, PF Song, YQ Song… - Bioorganic …, 2020 - Elsevier
Abstract Human Carboxylesterase 2A (hCES2A), one of the most important serine
hydrolases, plays crucial roles in the hydrolysis and the metabolic activation of a wide range …
hydrolases, plays crucial roles in the hydrolysis and the metabolic activation of a wide range …
Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors
Y Yang, Y Xiong, G Zhu, M Sun, K Zou, Y Zhao… - Chemico-Biological …, 2023 - Elsevier
Abstract Human carboxylesterase 2A (hCES2A) is a key serine hydrolase responsible for
the metabolic clearance of large number of compounds bearing the ester-or amide-bond (s) …
the metabolic clearance of large number of compounds bearing the ester-or amide-bond (s) …
Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1
PF Song, YD Zhu, HY Ma, YN Wang, DD Wang… - Fitoterapia, 2019 - Elsevier
Abstract Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes,
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …
Design, synthesis, and biological evaluation studies of novel carboxylesterase 2 inhibitors for the treatment of irinotecan-induced delayed diarrhea
Z Yang, Z Cao, W Wang, Y Chen, W Huang, S Jiao… - Bioorganic …, 2023 - Elsevier
Abstract Human carboxylesterase 2 (hCES2A), one of the most important serine hydrolases
distributed in the small intestine and colon, plays a crucial role in the hydrolysis of various …
distributed in the small intestine and colon, plays a crucial role in the hydrolysis of various …
[HTML][HTML] Structure-activity relationships of pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1
Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed
in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic …
in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic …
Discovery of a highly specific and efficacious inhibitor of human carboxylesterase 2 by large-scale screening
YQ Song, XQ Guan, ZM Weng, YQ Wang… - International journal of …, 2019 - Elsevier
Abstract Human carboxylesterase 2 (CES2A), one of the most abundant hydrolases
distributed in human small intestine and colon, play key roles in the hydrolysis of a wide …
distributed in human small intestine and colon, play key roles in the hydrolysis of a wide …
New bysspectin A derivatives as potent inhibitors of human carboxylesterase 2A
W Li, Y Zhang, Y Wu, G Zhu, X Liu, Y Song, B Ma… - European Journal of …, 2023 - Elsevier
Abstract Human carboxylesterase 2A (hCES2A), the most abundant carboxylesterase in the
human gut, plays a crucial role in the metabolic clearance and activation of various ester …
human gut, plays a crucial role in the metabolic clearance and activation of various ester …
Discovery of hCES2A inhibitors from Glycyrrhiza inflata via combination of docking-based virtual screening and fluorescence-based inhibition assays
YQ Song, XQ Guan, ZM Weng, JL Liu, J Chen… - Food & function, 2021 - pubs.rsc.org
Human carboxylesterase 2 (hCES2A) is a key target to ameliorate the intestinal toxicity
triggered by irinotecan that causes severe diarrhea in 50%–80% of patients receiving this …
triggered by irinotecan that causes severe diarrhea in 50%–80% of patients receiving this …
[HTML][HTML] Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2
YQ Song, RJ He, D Pu, XQ Guan, JH Shi… - Frontiers in …, 2021 - frontiersin.org
Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the
small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …
small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …
Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2
Human carboxylesterases (hCEs) are key enzymes from the serine hydrolase superfamily.
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …