Age-related cerebrovascular dysfunction plays a critical role in the pathogenesis of
cerebrovascular disease, vascular dementia and Alzheimer's disease, but therapeutic …

Autophagy is an essential cellular quality control process that has emerged as a critical one
for vascular homeostasis. Here, we show that trichoplein (TCHP) links autophagy with …

Protocadherins (Pcdhs) are a large family of cadherin-related molecules. They play a role in
cell adhesion, cellular interactions, and development of the central nervous system …

Inflammation of the central nervous system (CNS) is associated with diseases such as
multiple sclerosis, stroke and neurodegenerative diseases. Compromised integrity of the …

Background: As important components of the blood-brain barrier (BBB), brain endothelial
cells (ECs) interact with pericytes, astrocytes, neurons, microglia and extracellular matrix in …

Although tight‐junctions (TJs) at the blood–brain barrier (BBB) are important to prevent non‐
specific entry of compounds into the CNS, molecular mechanisms regulating TJ …

Ischemic stroke (IS) has become a cerebrovascular disease of widespread concern.
Overexpression of circUCK2 alleviates neuronal damage in IS. However, the specific …

Emerging studies have revealed new roles for the neural extracellular matrix in
neuropathologies. The structure of this matrix is unusual and uniquely enriched in …

The central nervous system (CNS) has specific barriers that protect the brain from potential
threats and tightly regulate molecular transport. Despite the critical functions of the CNS …

The blood–brain barrier (BBB) provides optimal conditions for the functioning of brain
neurons. The barrier properties of the cerebrovascular (CV) endothelium are determined by …