Alzheimer's disease (AD) is the most common cause of dementia in elderly people. Because
of the lack of effective treatments for this illness, research focused on identifying compounds …

The 5-HT5A receptor is a member of a new subfamily of serotonin [5-hydroxytryptamine (5-
HT)] receptors recently cloned from the human and rodent brain. The role of this receptor in …

Serotonin receptors of the 5-HT2A subtype are robustly expressed in the cerebral cortex
where they have been implicated in the pathophysiology and therapeutics of mental …

Like most neurotransmitters, serotonin possesses a simple structure. However, the
pharmacological consequences are more complex and diverse. Serotonin is involved in …

To investigate the possible functional relationship between 5-HT 1 and 5-HT 2 receptors, we
studied the effects of a nonselective 5-HT agonist (5-MeO DMT), a 5-HT 1A-selective (8-OH …

We assessed the activity of F15599, a selective and high efficacy 5-HT1A agonist that
preferentially activates post-versus pre-synaptic receptors, in rat cognition/memory models …

5-HT2 receptors are G-protein coupled receptors that currently comprise threesubtypes: 5-
HT2A, 5-HT2B and 5-HT2C receptors. The subtypes are related in theirmolecular structure …

There has been tremendous interest in 5-HT 3 receptor antagonists since their discovery
and the subsequent identification of 5-HT 3 receptors in the CNS. Based on the results of …

HT2Rs have a different genomic organization from other 5-HT2Rs. 5HT2CR undergoes post-
transcriptional pre-mRNA editing generating diversity among RNA transcripts. Selective post …

The involvement of the cholinergic system in learning and memory together with the
cognitive enhancing properties of 5‐HT6 receptor antagonists led us to study the …