[HTML][HTML] Synthesis of Fmoc-triazine amino acids and its application in the synthesis of short antibacterial peptidomimetics
P Gunasekaran, EY Kim, J Lee, EK Ryu… - International Journal of …, 2020 - mdpi.com
To combat the escalating rise of antibacterial resistance, the development of antimicrobial
peptides (AMPs) with a unique mode of action is considered an attractive strategy. However …
peptides (AMPs) with a unique mode of action is considered an attractive strategy. However …
Host defense antimicrobial peptides as antibiotics: design and application strategies
Highlights•Antibiotic resistance is a serious problem of our era.•Antimicrobial peptides are
important templates for developing new antibiotics.•Both peptide discovery and application …
important templates for developing new antibiotics.•Both peptide discovery and application …
Design and discovery of new antibacterial agents: Advances, perspectives, challenges
J Jampilek - Current medicinal chemistry, 2018 - ingentaconnect.com
Background: Emerging resistance of bacterial pathogens to clinically used drugs, including
not only first-choice but also second-and third-choice drugs, is alarming, but since the 1990s …
not only first-choice but also second-and third-choice drugs, is alarming, but since the 1990s …
[HTML][HTML] Special Issue “Peptides for Health Benefits 2021”
C Martínez-Villaluenga… - International Journal of …, 2024 - mdpi.com
In recent years, non-communicable diseases (NCDs) have increased in prevalence in our
society and have become a serious burden of disease worldwide. More than 50% of all …
society and have become a serious burden of disease worldwide. More than 50% of all …
[HTML][HTML] The potential of antimicrobial peptides as biocides
G Laverty, SP Gorman, BF Gilmore - International journal of molecular …, 2011 - mdpi.com
Antimicrobial peptides constitute a diverse class of naturally occurring antimicrobial
molecules which have activity against a wide range of pathogenic microorganisms …
molecules which have activity against a wide range of pathogenic microorganisms …
[HTML][HTML] Lights and shadows on the therapeutic use of antimicrobial peptides
D Bellotti, M Remelli - Molecules, 2022 - mdpi.com
The emergence of antimicrobial-resistant infections is still a major concern for public health
worldwide. The number of pathogenic microorganisms capable of resisting common …
worldwide. The number of pathogenic microorganisms capable of resisting common …
[HTML][HTML] Bioactive antimicrobial peptides: A new weapon to counteract zoonosis
L Zupin, CA Santos-Silva, ARH Al Mughrbi, LMB Vilela… - Microorganisms, 2022 - mdpi.com
Zoonoses have recently become the center of attention of the general population and
scientific community. Notably, more than 30 new human pathogens have been identified in …
scientific community. Notably, more than 30 new human pathogens have been identified in …
Antimicrobial lipopeptaibol trichogin GA IV: role of the three Aib residues on conformation and bioactivity
M De Zotti, B Biondi, Y Park, KS Hahm, M Crisma… - Amino Acids, 2012 - Springer
The lipopeptaibol trichogin GA IV is a natural, non-ribosomally synthesized, antimicrobial
peptide remarkably resistant to the action of hydrolytic enzymes. This feature may be …
peptide remarkably resistant to the action of hydrolytic enzymes. This feature may be …
[HTML][HTML] Synthetic antimicrobial peptides: From choice of the best sequences to action mechanisms
PFN Souza, LSM Marques, JTA Oliveira, PG Lima… - Biochimie, 2020 - Elsevier
The emergence of antibiotic-resistant microbes has stimulated research worldwide seeking
new biologically active molecules. In this respect, synthetic antimicrobial peptides (SAMPs) …
new biologically active molecules. In this respect, synthetic antimicrobial peptides (SAMPs) …
[HTML][HTML] Physicochemical-guided design of cathelicidin-derived peptides generates membrane active variants with therapeutic potential
NGJ Oliveira, MH Cardoso, N Velikova, M Giesbers… - Scientific Reports, 2020 - nature.com
The spread of multi-drug resistance and the slow pace at which antibiotics come onto the
market are undermining our ability to treat human infections, leading to high mortality rates …
market are undermining our ability to treat human infections, leading to high mortality rates …