Design and discovery of new antibacterial agents: Advances, perspectives, challenges

J Jampilek - Current medicinal chemistry, 2018 - ingentaconnect.com
Background: Emerging resistance of bacterial pathogens to clinically used drugs, including
not only first-choice but also second-and third-choice drugs, is alarming, but since the 1990s …

Synthetic antimicrobial peptidomimetics with therapeutic potential

BE Haug, W Stensen, M Kalaaji, Ø Rekdal… - Journal of medicinal …, 2008 - ACS Publications
A series of synthetic antimicrobial peptidomimetics (SAMPs) have been prepared and found
to be highly active against several Gram-negative and Gram-positive bacterial strains. These …

Characterization and in vitro Analysis of Probiotic-Derived Peptides Against Multi Drug Resistance Bacterial Infections

A Mazumdar, Y Haddad, VP Sur… - Frontiers in …, 2020 - frontiersin.org
An inexorable switch from antibiotics has become a major desideratum to overcome
antibiotic resistance. Bacteriocin from Lactobacillus casei, a cardinal probiotic was used to …

[HTML][HTML] Rationally designed antimicrobial peptides: Insight into the mechanism of eleven residue peptides against microbial infections

G Pandit, K Biswas, S Ghosh, S Debnath… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The widespread abuse of antibiotics has led to the use of antimicrobial peptides (AMPs) as a
replacement for the existing conventional therapeutic agents for combating microbial …

Chemically modified and conjugated antimicrobial peptides against superbugs

W Li, F Separovic, NM O'Brien-Simpson… - Chemical Society …, 2021 - pubs.rsc.org
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

Medium-sized peptides from microbial sources with potential for antibacterial drug development

J Chen, W Wang, X Hu, Y Yue, X Lu, C Wang… - Natural Product …, 2024 - pubs.rsc.org
Covering: 1993 to the end of 2022As the rapid development of antibiotic resistance shrinks
the number of clinically available antibiotics, there is an urgent need for novel options to fill …

New antimicrobial hexapeptides: Synthesis, antimicrobial activities, cytotoxicity, and mechanistic studies

RK Sharma, S Sundriyal, N Wangoo… - ChemMedChem …, 2010 - Wiley Online Library
Synthetic antimicrobial peptides have recently emerged as promising candidates against
drug‐resistant pathogens. We identified a novel hexapeptide, Orn‐d‐Trp‐d‐Phe‐Ile‐d‐Phe …

In pursuit of next-generation therapeutics: Antimicrobial peptides against superbugs, their sources, mechanism of action, nanotechnology-based delivery, and clinical …

A Thakur, A Sharma, HK Alajangi, PK Jaiswal… - International Journal of …, 2022 - Elsevier
Antimicrobial peptides (AMPs) attracted attention as potential source of novel antimicrobials.
Multi-drug resistant (MDR) infections have emerged as a global threat to public health in …

Archetypal tryptophan-rich antimicrobial peptides: properties and applications

N Shagaghi, EA Palombo, AHA Clayton… - World Journal of …, 2016 - Springer
Abstract Drug-resistant microorganisms ('superbugs') present a serious challenge to the
success of antimicrobial treatments. Subsequently, there is a crucial need for novel bio …

Recent advances in antimicrobial peptide-based therapy

A Mulukutla, R Shreshtha, VK Deb, P Chatterjee… - Bioorganic …, 2024 - Elsevier
Antimicrobial peptides (AMPs) are a group of polypeptide chains that have the property to
target and kill a myriad of microbial organisms including viruses, bacteria, protists, etc. The …