New antimicrobial hexapeptides: Synthesis, antimicrobial activities, cytotoxicity, and mechanistic studies

RK Sharma, S Sundriyal, N Wangoo… - ChemMedChem …, 2010 - Wiley Online Library
Synthetic antimicrobial peptides have recently emerged as promising candidates against
drug‐resistant pathogens. We identified a novel hexapeptide, Orn‐d‐Trp‐d‐Phe‐Ile‐d‐Phe …

In pursuit of next-generation therapeutics: Antimicrobial peptides against superbugs, their sources, mechanism of action, nanotechnology-based delivery, and clinical …

A Thakur, A Sharma, HK Alajangi, PK Jaiswal… - International Journal of …, 2022 - Elsevier
Antimicrobial peptides (AMPs) attracted attention as potential source of novel antimicrobials.
Multi-drug resistant (MDR) infections have emerged as a global threat to public health in …

Chemically modified and conjugated antimicrobial peptides against superbugs

W Li, F Separovic, NM O'Brien-Simpson… - Chemical Society …, 2021 - pubs.rsc.org
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

Discovery, optimization, and clinical application of natural antimicrobial peptides

AA Rodríguez, A Otero-González, M Ghattas… - Biomedicines, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are widespread in multicellular organisms. These structurally
diverse molecules are produced as the first line of defense against pathogens such as …

Antimicrobial peptides: Molecular design, structure-function relationship, and biosynthesis optimization

Y Hao, J Wang, C de la Fuente-Nunez… - Frontiers in …, 2022 - frontiersin.org
The long-term use of antibiotics has accelerated the emergence of antibiotic-resistant
bacteria (ARB). Annual global death due to antibiotic resistance is over 700,000 in 2014, it is …

[PDF][PDF] Peptide antibiotics developed by mimicking natural antimicrobial peptides

N Unubol, S Selim Cinaroglu, MA Elmas, S Akcelik… - Clin …, 2017 - researchgate.net
Antimicrobial peptides are widely preferred drugs for infectious disease treatment. Inspired
from natural antimicrobial peptides, short peptides showing good antibacterial activity are …

Spotlight on the selected new antimicrobial innate immune peptides discovered during 2015-2019

X Dang, G Wang - Current topics in medicinal chemistry, 2020 - ingentaconnect.com
Background: Antibiotic resistance is a global issue and new anti-microbials are required.
Introduction: Anti-microbial peptides are important players of host innate immune systems …

Archetypal tryptophan-rich antimicrobial peptides: properties and applications

N Shagaghi, EA Palombo, AHA Clayton… - World Journal of …, 2016 - Springer
Abstract Drug-resistant microorganisms ('superbugs') present a serious challenge to the
success of antimicrobial treatments. Subsequently, there is a crucial need for novel bio …

Recent advances in antimicrobial peptide-based therapy

A Mulukutla, R Shreshtha, VK Deb, P Chatterjee… - Bioorganic …, 2024 - Elsevier
Antimicrobial peptides (AMPs) are a group of polypeptide chains that have the property to
target and kill a myriad of microbial organisms including viruses, bacteria, protists, etc. The …

Antimicrobial peptide mimics for clinical use: does size matter?

J Svenson, N Molchanova, CI Schroeder - Frontiers in Immunology, 2022 - frontiersin.org
The search for efficient antimicrobial therapies that can alleviate suffering caused by
infections from resistant bacteria is more urgent than ever before. Infections caused by multi …