Stalled RNA polymerases (RNAPs) pose an obstacle for the replicating complexes, which
could lead to transcription-replication conflicts and result in genetic instability. Stalled …

In nature bacteria rarely meet conditions of unlimited growth and most of their lives are
exposed to variating and harsh environmental conditions. Numerous strategies to overcome …

Transcription‐coupled repair (TCR) is a phenomenon that exists in a wide variety of
organisms from bacteria to humans. This mechanism allows cells to repair the actively …

The mfd (mutation frequency decline) gene was identified by screening an auxotrophic
Escherichia coli strain exposed to UV and held in a minimal medium before plating onto rich …

Nucleotide excision repair (NER) is one of the most important repair systems which
counteracts different forms of DNA damage either induced by various chemicals or …

Highlights•UvrD is the first transcription factor that forces RNA polymerase to
backtrack.•Elongation factor NusA assists UvrD in stimulating backtracking.•UvrD/NusA …

Transcription-coupled DNA repair (TCR) is a subpathway of nucleotide excision repair
(NER) that is triggered when RNA polymerase is stalled by DNA damage. Lesions targeted …

DNA damage that blocks the transcription of genes is prioritized for repair by transcription-
coupled DNA repair pathways. RNA polymerases stalled at DNA lesions obstruct repair …

Transcription-coupled nucleotide excision repair (TCR) accelerates the removal of
noncoding lesions from the template strand of active genes, and hence contributes to …

The transcription repair coupling factor Mfd removes stalled RNA polymerase from DNA
lesions and links transcription to UvrABC-dependent nucleotide excision repair in …