Abstract β1 integrins (β1) transduce mechanical signals in many cells, including cardiac
myocytes (CM). Given their close localization, as well as their role in mechanotransduction …

Recently, development of a caveolin-1-deficient (Cav-1 null) mouse model has allowed the
detailed analysis of caveolin-1's function in the context of a whole animal. Interestingly, we …

A growing body of evidence suggests that muscle cell caveolae may function as specialized
membrane micro-domains in which the dystrophin-glycoprotein complex and cellular …

Caveolae are becoming increasingly recognized as an important organizational structure for
a variety of signal and energy-transducing systems in vascular smooth muscle (VSM). In this …

Highlights•Caveolae are lined with a caveolin coat covered by a network of cavin
filaments.•Cavins are the more labile component of the caveolar coat complex.•Caveolae …

For more than two decades, investigators who have been studying signal transduction in the
heart (and other tissues) have struggled to explain data implicating the existence of …

Whether ventricular cardiac myocytes of mouse contain caveolin-1 is disputed. It has been
claimed to be exclusively in nearby endothelial cell profiles. Recently, matrix …

To identify the role of caveolin-1 in integrin mechanotransduction, we exposed bovine aortic
endothelial cells to 10 dyn/cm2 of laminar shear stress. Caveolin-1 was acutely and …

Pathological cardiac hypertrophy is characterized by subcellular remodeling of the
ventricular myocyte with a reduction in the scaffolding protein caveolin-3 (Cav-3), altered Ca …

Caveolin-3 the muscle-specific caveolin isoform, acts like the more ubiquitously expressed
caveolin-1 to sculpt caveolae, specialized membrane microdomains that serve as platforms …