13066 Background: Perifosine is an alkylphospholipid that modulates several signal
transduction pathways, including Akt, which is often activated in taxane resistant tumors and …

Background Activated AKT is a marker of decreased event-free or overall survival in
neuroblastoma (NB) patients. The aim of this study was to investigate the effect of perifosine …

PURPOSE: Perifosine is an orally applicable, membrane-targeted alkylphosphocholine
analogue with antitumour activity and radiosensitising properties in preclinical models. The …

Abstract BACKGROUND. A multicenter Phase II study was performed to evaluate the clinical
activity of an initial loading (150 mg every 6 hours× 4 doses) dose followed by continuous …

Activation of the PI3K/Akt pathway is associated with the development of numerous human
cancers. As a result, many emerging therapies target this pathway. Previous studies have …

Targeted therapies have brought the treatment of many cancers to a level of success
surpassing that witnessed with traditional chemotherapeutic and immunosuppressive …

Abstract 1823 Introduction: Perifosine is a synthetic alkylphosholipid which has been shown
to inhibit Akt activity and has demonstrated promising activity in patients with advanced RCC …

Publisher Summary This chapter discusses small molecule inhibitors of AKT/PKB kinase as
a strategy for treating cancer. In studies the 2-pyrimidyl-5-amidothiophene has been …

Perifosine belongs to the class of alkylphospholipid analogues, which act primarily at the
cell membrane, thereby targeting signal transduction pathways. In phase I/II clinical trials …

Purpose: Antineoplastic agents often achieve antitumor activity at the expense of close to
unacceptable toxicity. One potential avenue to improve therapeutic index might combine …