Objective—Liver X–activated receptor α (LXRα) regulates multiple genes controlling
cholesterol metabolism and transport. To clarify its role in atherogenesis, we established a …

Background—The nuclear liver X receptor-α (LXR-α) has been implicated in the regulation
of intracellular cholesterol homeostasis, inflammatory response, and atherosclerosis …

Objective—Complications of atherosclerotic cardiovascular disease due to elevated blood
cholesterol levels are the major cause of death in the Western world. The liver X receptors …

The nuclear oxysterol receptors LXRα (NR1H3) and LXRβ (NR1H2) coordinately regulate
the expression of genes involved in the transport and catabolism of cholesterol. In …

Liver X activated receptor alpha (LXRα) forms a functional dimeric nuclear receptor with
RXR that regulates the metabolism of several important lipids, including cholesterol and bile …

Recent studies on the liver X receptor-α (LXR-α) have recognized its crucial protective role
in the initiation of a cross-talk between lipid metabolism and inflammation regarded as a …

The liver X receptors LXRα and LXRβ play critical roles in maintaining lipid homeostasis by
functioning as transcription factors that regulate genetic networks controlling the transport …

IL-5 stimulates production of T15/EO6 IgM antibodies that can block the uptake of oxidized
low density lipoprotein by macrophages, whereas a deficiency in macrophage IL-5 …

In order to identify changes in the gene expression profile during human monocyte/
macrophage differentiation in the presence of GM-CSF, the expression level of various …

Recent studies have identified the liver X receptors (LXRα and LXRβ) as important
regulators of cholesterol metabolism and transport. LXRs control transcription of genes …