Several lines of evidence support the involvement of serotonergic (5-HT) neurons of the
median raphe nucleus (MRN) in anxiety-like behaviour. In this context, it is known that …

Several lines of evidence have demonstrated a role for the lateral hypothalamus (LH) in an
endogenous system of descending inhibition. Descending inhibition from the LH relies, at …

In single cell experiments, the characterization of the responses of medial thalamic neurons
to noxious and nonnoxious stimulation was made to examine the effects of two substances …

The ventral part of the medial prefrontal cortex (mPFC) plays an important role in mood and
cognition. This study examined the effect of the 5-HT in this region by measuring the …

The morphology and electrophysiological properties of serotonergic and non-serotonergic
projection neurons in the dorsal raphe nucleus (DRN) of the rat were examined in frontal …

Descending brainstem control of spinal nociceptive processing permits a dynamic and
adaptive modulation of ascending sensory information. Chronic pain states are frequently …

Thresholds to noxious heat stimulation were increased following microinjection of
zimelidine, an inhibitor of 5-hydroxytryptamine (5-HT) re-uptake, into the nucleus raphe …

The mechanisms and sites of action of epibatidine-induced antinociception and side effects
are poorly understood. The present study tested the hypothesis that the serotonergic dorsal …

The dorsal raphe nucleus (DRN) is the origin of the central serotonin [5-hydroxytryptamine
(5-HT)] system and plays an important role in the regulation of many physiological functions …

Supraspinal opioid analgesia is mediated in part by connections between the midbrain
periaqueductal gray (PAG) and the ventral-medial medulla, including the nucleus raphe …