Identification of HPV oncogene and host cell differentiation associated cellular heterogeneity in cervical cancer via single‐cell transcriptomic analysis
Abstract Human Papillomaviruses (HPVs) are associated with around 5%–10% of human
cancer, notably nearly 99% of cervical cancer. The mechanisms HPV interacts with stratified …
cancer, notably nearly 99% of cervical cancer. The mechanisms HPV interacts with stratified …
Single‐cell RNA‐sequencing dissects cellular heterogeneity and identifies two tumor‐suppressing immune cell subclusters in HPV‐related cervical adenosquamous …
X Li, M Zhang, T Lei, W Zou, R Huang… - Journal of Medical …, 2022 - Wiley Online Library
The intratumor heterogeneity of human papillomavirus (HPV)‐related cervical cancer
remains poorly defined. We performed single‐cell RNA sequencing on 18 046 individual …
remains poorly defined. We performed single‐cell RNA sequencing on 18 046 individual …
Single‐cell transcriptomics dissects epithelial heterogeneity in HPV+ cervical adenocarcinoma
C Wang, L Li, F Wang, X Li, J Sun, X Li… - Journal of Medical …, 2023 - Wiley Online Library
The intra‐and intertumoral heterogeneity of epithelial cells in human papillomavirus (HPV+)
cervical adenocarcinoma (CEAD) remains largely unknown. To investigate this issue, we …
cervical adenocarcinoma (CEAD) remains largely unknown. To investigate this issue, we …
Effect of productive human papillomavirus 16 infection on global gene expression in cervical epithelium
Human papillomavirus (HPV) infection is the world's most common sexually transmitted
infection and is responsible for most cases of cervical cancer. Previous studies of global …
infection and is responsible for most cases of cervical cancer. Previous studies of global …
Expression profiling of mRNA and functional network analyses of genes regulated by human papilloma virus E6 and E7 proteins in HaCaT cells
R Dai, R Tao, X Li, T Shang, S Zhao… - Frontiers in Microbiology, 2022 - frontiersin.org
Human papillomavirus (HPV) oncogenes E6 and E7 are essential for HPV-related cancer
development. Here, we developed a cell line model using lentiviruses for transfection of the …
development. Here, we developed a cell line model using lentiviruses for transfection of the …
Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer
X Lu, Q Lin, M Lin, P Duan, L Ye, J Chen, X Chen… - PLoS …, 2014 - journals.plos.org
The constitutive expression of the high-risk HPV E6 and E7 viral oncogenes is the major
cause of cervical cancer. To comprehensively explore the composition of HPV16 early …
cause of cervical cancer. To comprehensively explore the composition of HPV16 early …
Diverse intratumoral heterogeneity and immune microenvironment of two HPV‐related cervical cancer types revealed by single‐cell RNA sequencing
C Li, D Liu, Y Zhao, Y Ding… - Journal of Medical Virology, 2023 - Wiley Online Library
Cervical squamous cell carcinoma (SCC) and adenocarcinoma (AD) are the main
histological types of human papillomavirus‐related cervical cancer. However, there are few …
histological types of human papillomavirus‐related cervical cancer. However, there are few …
Single‐cell transcriptomic analysis of the role of HPV16‐positive macrophages in cervical cancer prognosis
Almost all cases of cervical cancer (CC) can be attributed to high‐risk human papillomavirus
(HPVs) infections in keratinocytes. However, it is unknown whether HPV invades immune …
(HPVs) infections in keratinocytes. However, it is unknown whether HPV invades immune …
Combined transcriptome and proteome analysis of immortalized human keratinocytes expressing human papillomavirus 16 (HPV16) oncogenes reveals novel key …
R Yang, J Klimentová, E Göckel-Krzikalla, R Ly… - Msphere, 2019 - Am Soc Microbiol
Although the role of high-risk human papillomaviruses (hrHPVs) as etiological agents in
cancer development has been intensively studied during the last decades, there is still the …
cancer development has been intensively studied during the last decades, there is still the …
Transcriptome sequencing profiles of cervical cancer tissues and SiHa cells
T Chen, S Yang, J Xu, W Lu, X Xie - Functional & integrative genomics, 2020 - Springer
High-risk human papillomavirus (HPV) is a causal factor for cervical cancer, of which HPV16
is the predominant genotype, but the detailed mechanism remains to be elucidated. In this …
is the predominant genotype, but the detailed mechanism remains to be elucidated. In this …
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