Identification of HPV oncogene and host cell differentiation associated cellular heterogeneity in cervical cancer via single‐cell transcriptomic analysis

Y Li, C Wang, A Ma, AQ Rani, M Luo… - Journal of Medical …, 2023 - Wiley Online Library
Abstract Human Papillomaviruses (HPVs) are associated with around 5%–10% of human
cancer, notably nearly 99% of cervical cancer. The mechanisms HPV interacts with stratified …

Single‐cell RNA‐sequencing dissects cellular heterogeneity and identifies two tumor‐suppressing immune cell subclusters in HPV‐related cervical adenosquamous …

X Li, M Zhang, T Lei, W Zou, R Huang… - Journal of Medical …, 2022 - Wiley Online Library
The intratumor heterogeneity of human papillomavirus (HPV)‐related cervical cancer
remains poorly defined. We performed single‐cell RNA sequencing on 18 046 individual …

Single‐cell transcriptomics dissects epithelial heterogeneity in HPV+ cervical adenocarcinoma

C Wang, L Li, F Wang, X Li, J Sun, X Li… - Journal of Medical …, 2023 - Wiley Online Library
The intra‐and intertumoral heterogeneity of epithelial cells in human papillomavirus (HPV+)
cervical adenocarcinoma (CEAD) remains largely unknown. To investigate this issue, we …

Effect of productive human papillomavirus 16 infection on global gene expression in cervical epithelium

SD Kang, S Chatterjee, S Alam, AC Salzberg… - Journal of …, 2018 - Am Soc Microbiol
Human papillomavirus (HPV) infection is the world's most common sexually transmitted
infection and is responsible for most cases of cervical cancer. Previous studies of global …

Expression profiling of mRNA and functional network analyses of genes regulated by human papilloma virus E6 and E7 proteins in HaCaT cells

R Dai, R Tao, X Li, T Shang, S Zhao… - Frontiers in Microbiology, 2022 - frontiersin.org
Human papillomavirus (HPV) oncogenes E6 and E7 are essential for HPV-related cancer
development. Here, we developed a cell line model using lentiviruses for transfection of the …

Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer

X Lu, Q Lin, M Lin, P Duan, L Ye, J Chen, X Chen… - PLoS …, 2014 - journals.plos.org
The constitutive expression of the high-risk HPV E6 and E7 viral oncogenes is the major
cause of cervical cancer. To comprehensively explore the composition of HPV16 early …

Diverse intratumoral heterogeneity and immune microenvironment of two HPV‐related cervical cancer types revealed by single‐cell RNA sequencing

C Li, D Liu, Y Zhao, Y Ding… - Journal of Medical Virology, 2023 - Wiley Online Library
Cervical squamous cell carcinoma (SCC) and adenocarcinoma (AD) are the main
histological types of human papillomavirus‐related cervical cancer. However, there are few …

Single‐cell transcriptomic analysis of the role of HPV16‐positive macrophages in cervical cancer prognosis

S Wang, X Li, C Liu, Y Yuan, F Ma - Journal of Medical Virology, 2023 - Wiley Online Library
Almost all cases of cervical cancer (CC) can be attributed to high‐risk human papillomavirus
(HPVs) infections in keratinocytes. However, it is unknown whether HPV invades immune …

Combined transcriptome and proteome analysis of immortalized human keratinocytes expressing human papillomavirus 16 (HPV16) oncogenes reveals novel key …

R Yang, J Klimentová, E Göckel-Krzikalla, R Ly… - Msphere, 2019 - Am Soc Microbiol
Although the role of high-risk human papillomaviruses (hrHPVs) as etiological agents in
cancer development has been intensively studied during the last decades, there is still the …

Transcriptome sequencing profiles of cervical cancer tissues and SiHa cells

T Chen, S Yang, J Xu, W Lu, X Xie - Functional & integrative genomics, 2020 - Springer
High-risk human papillomavirus (HPV) is a causal factor for cervical cancer, of which HPV16
is the predominant genotype, but the detailed mechanism remains to be elucidated. In this …