Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials

AS Antonopoulos, M Margaritis, R Lee… - Current …, 2012 - ingentaconnect.com
Ample evidence exists in support of the potent anti-inflammatory properties of statins. In cell
studies and animal models statins exert beneficial cardiovascular effects. By inhibiting …

Anti-inflammatory effects of statins: clinical evidence and basic mechanisms

MK Jain, PM Ridker - Nature reviews Drug discovery, 2005 - nature.com
Chronic inflammation is a key feature of vascular disease states such as atherosclerosis.
Multiple clinical studies have shown that a class of medications termed statins lower …

Update on statin-mediated anti-inflammatory activities in atherosclerosis

F Montecucco, F Mach - Seminars in immunopathology, 2009 - Springer
Anti-inflammatory activities of statins in atherosclerosis have been well documented by both
basic research and clinical studies. Statins have been introduced in the 1980s as 3-hydroxy …

Statins reduce vascular inflammation in atherogenesis: a review of underlying molecular mechanisms

L Liberale, F Carbone, F Montecucco… - The international journal …, 2020 - Elsevier
Chronic inflammation enhances the detrimental role of dyslipidaemia during atherogenesis.
Statins are among the most effective anti-atherosclerotic medications, being able to impact …

Statins and inflammation: an update

P Quist-Paulsen - Current opinion in cardiology, 2010 - journals.lww.com
Statins and inflammation: an update : Current Opinion in Cardiology Statins and inflammation:
an update : Current Opinion in Cardiology Log in or Register Subscribe to journalSubscribe …

Are statins anti-inflammatory?

GJ Blake, PM Ridker - Trials, 2000 - Springer
Large scale clinical trials demonstrate significant reductions in cardiovascular event rates
with statin therapy. The observed benefit of statin therapy, however, may be larger in these …

Statins and inflammation

M Satny, JA Hubacek, M Vrablik - Current atherosclerosis reports, 2021 - Springer
Abstract Purpose of Review Chronic inflammation has been recognized as one of the most
important pathophysiological mechanisms' initiation and progression of atherosclerosis …

Inflammatory markers, cholesterol and statins: pathophysiological role and clinical importance

LM Biasucci, G Biasillo, A Stefanelli - Clinical chemistry and …, 2010 - degruyter.com
Statins are one of the most important medications in cardio-vascular diseases since they
block cholesterol synthesis by inhibiting the 3-hydroxy-3-methylglutaryl coenzyme A …

Innate and adaptive inflammation as a therapeutic target in vascular disease: the emerging role of statins

D Tousoulis, C Psarros, M Demosthenous… - Journal of the American …, 2014 - jacc.org
Atherosclerosis, the main pathophysiological condition leading to cardiovascular disease
(CVD), is now considered to be a chronic inflammatory condition. Statins are the most widely …

Cellular and molecular mechanisms of statins: an update on pleiotropic effects

M Satoh, Y Takahashi, T Tabuchi, Y Minami… - Clinical …, 2015 - portlandpress.com
Coronary artery disease (CAD) is the leading cause of death worldwide. The efficacy and
safety of statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) in primary …