[HTML][HTML] Chronic and acute intranasal oxytocin produce divergent social effects in mice

H Huang, C Michetti, M Busnelli, F Manago… - …, 2014 - nature.com
Intranasal administration of oxytocin (OXT) might be a promising new adjunctive therapy for
mental disorders characterized by social behavioral alterations such as autism and …

Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques

ME Modi, F Connor-Stroud, R Landgraf… - …, 2014 - Elsevier
Intranasal (IN) administration is a widely used method for examining the effect of oxytocin
(OT) on social behavior and cognition in healthy subjects and psychiatric populations. IN-OT …

[HTML][HTML] Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
Reports on the modulatory role of the neuropeptide oxytocin on social cognition and
behavior have steadily increased over the last two decades, stimulating considerable …

[HTML][HTML] Long-term exposure to intranasal oxytocin in a mouse autism model

KL Bales, M Solomon, S Jacob, JN Crawley… - Translational …, 2014 - nature.com
Oxytocin (OT) is a neuropeptide involved in mammalian social behavior. It is currently in
clinical trials for the treatment of autism spectrum disorder (ASD). Previous studies in healthy …

Oxytocin delivered nasally or intraperitoneally reaches the brain and plasma of normal and oxytocin knockout mice

AS Smith, AC Korgan, WS Young - Pharmacological research, 2019 - Elsevier
Intranasal delivery of oxytocin (Oxt) has been identified as a potential therapeutic to target
human conditions characterized by social deficits, yet the ability of this administrative route …

Acute and repeated intranasal oxytocin administration exerts anti-aggressive and pro-affiliative effects in male rats

F Calcagnoli, JC Kreutzmann, SF de Boer… - …, 2015 - Elsevier
Socio-emotional deficits and impulsive/aggressive outbursts are prevalent symptoms of
many neuropsychiatric disorders, and intranasal administration of oxytocin (OXT) is …

Intranasal oxytocin selectively attenuates rhesus monkeys' attention to negative facial expressions

LA Parr, M Modi, E Siebert, LJ Young - Psychoneuroendocrinology, 2013 - Elsevier
Intranasal oxytocin (IN-OT) modulates social perception and cognition in humans and could
be an effective pharmacotherapy for treating social impairments associated with …

[HTML][HTML] A spatiotemporal profile of in vivo cerebral blood flow changes following intranasal oxytocin in humans

Y Paloyelis, OM Doyle, FO Zelaya, S Maltezos… - Biological …, 2016 - Elsevier
Background Animal and human studies highlight the role of oxytocin in social cognition and
behavior and the potential of intranasal oxytocin (IN-OT) to treat social impairment in …

Overview of human oxytocin research

KM Kendrick, AJ Guastella, B Becker - Behavioral pharmacology of …, 2018 - Springer
Social dysfunction is a core symptom of many psychiatric disorders and current medications
have little or no remedial effects on this. Following on from extensive studies on animal …

Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model

DS Quintana, GA Alvares, IB Hickie… - … & Biobehavioral Reviews, 2015 - Elsevier
Accumulating evidence demonstrates the important role of oxytocin (OT) in the modulation of
social cognition and behavior. This has led many to suggest that the intranasal …