Although the role of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway has been most extensively studied in hematopoietic cells and hematologic …

The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway is characterized by diverse immune regulatory systems involving cell proliferation …

In the past decades, studies of the Janus kinases (JAKs) and signal transducers and
activators of transcription (STATs) signaling have uncovered highly conserved programs …

Aberrant activation of intracellular signalling pathways confers malignant properties on
cancer cells. Targeting intracellular signalling pathways has been a productive strategy for …

Persistent JAK-STAT3 signaling is implicated in many aspects of tumorigenesis. Apart from
its tumor-intrinsic effects, STAT3 also exerts tumor-extrinsic effects, supporting tumor survival …

Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway is a
common signaling pathway used to transduce signals from the extracellular to the …

Aberrant activation of signal transducer and activator of transcription (STAT) proteins is
associated with the development and progression of solid tumors. However, as transcription …

Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …

STAT proteins become activated upon tyrosine and serine phosphorylation, are
subsequently translocated from the cytosol to the nucleus where they exert DNA-binding …