Single-cell transcriptomic profiling to evaluate the effects of Di (2-ethylhexyl) phthalate exposure on early meiosis of female mouse germ cells
Y Tian, Y Zhang, PY Dong, YH Sun, AH Zhao, W Shen… - Chemosphere, 2022 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) has proven characteristics of an endocrine-
disrupting compound (EDC), which can threaten the reproductive health of humans and …
disrupting compound (EDC), which can threaten the reproductive health of humans and …
Mechanisms of imbalanced testicular homeostasis in infancy due to aberrant histone acetylation in undifferentiated spermatogonia under different concentrations of Di …
Y Tian, J Guo, L Hua, Y Jiang, W Ge, X Zhang… - Environmental …, 2024 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP), identified as an endocrine-disrupting chemical,
is associated with reproductive toxicity. This association is particularly noteworthy in …
is associated with reproductive toxicity. This association is particularly noteworthy in …
H3K4me3 as a target of di (2-ethylhexyl) phthalate (DEHP) impairing primordial follicle assembly
MH Li, JJ Wang, YQ Feng, X Liu, ZH Yan, XJ Zhang… - Chemosphere, 2023 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a widely used plastics additive that growing
evidence indicates as endocrine disruptor able to negatively affect various reproductive …
evidence indicates as endocrine disruptor able to negatively affect various reproductive …
Single-cell transcriptomic dissection of the toxic impact of di (2-ethylhexyl) phthalate on immature testicular development at the neonatal stage
Y Wei, Y Hong, L Yang, J Wang, T Zhao… - Food and Chemical …, 2023 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) early exposure leads to immature testicular
injury, and we aimed to utilize single-cell RNA (scRNA) sequencing to comprehensively …
injury, and we aimed to utilize single-cell RNA (scRNA) sequencing to comprehensively …
[HTML][HTML] Single-cell transcriptome dissection of the toxic impact of Di (2-ethylhexyl) phthalate on primordial follicle assembly
JJ Wang, Y Tian, MH Li, YQ Feng, L Kong, FL Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Accumulated evidence indicates that environmental plasticizers are a threat to
human and animal fertility. Di (2-ethylhexyl) phthalate (DEHP), a plasticizer to which humans …
human and animal fertility. Di (2-ethylhexyl) phthalate (DEHP), a plasticizer to which humans …
Single-cell insights into mouse testicular toxicity under peripubertal exposure to di (2-ethylhexyl) phthalate
Y Li, Y Tian, M Xu, X Qiu, Z Bao, M Shi… - Toxicological …, 2024 - academic.oup.com
Male fertility depends on normal pubertal development. Di (2-ethylhexyl) phthalate (DEHP)
is a potent antiandrogen chemical, and exposure to DEHP during peripuberty can damage …
is a potent antiandrogen chemical, and exposure to DEHP during peripuberty can damage …
Multiple transcriptomic profiling: potential novel metabolism-related genes predict prepubertal testis damage caused by DEHP exposure
L Kang, J Chen, J Wang, T Zhao, Y Wei, Y Wu… - … Science and Pollution …, 2022 - Springer
The toxic effect of di (2-ethylhexyl) phthalate (DEHP) on prepubertal testes was examined in
this study. We treated 3-week-old male mice with 4.8 mg/kg/day (milligram/kilogram/day)(no …
this study. We treated 3-week-old male mice with 4.8 mg/kg/day (milligram/kilogram/day)(no …
Di (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal mouse oocytes in vitro
JC Liu, FN Lai, L Li, XF Sun, SF Cheng, W Ge… - Cell death & …, 2017 - nature.com
Abstract Di (2-ethylhexyl) phthalate (DEHP), is the most common member of the class of
phthalates that are used as plasticizers and have become common environmental …
phthalates that are used as plasticizers and have become common environmental …
Di-2-ethylhexyl phthalate (DEHP) exposure induces sperm quality and functional defects in mice
L XueXia, L YaNan, T Zi, Z YuSheng, W ZeLin, Z Peng… - Chemosphere, 2023 - Elsevier
Abstract Di-2-ethylhexyl phthalate (DEHP) harms mammalian testis development, yet the
specific mechanism of its effect on sperm quality and function is unclear. In this study, male …
specific mechanism of its effect on sperm quality and function is unclear. In this study, male …
Di(2-Ethylhexyl) Phthalate Exposure In Utero Damages Sertoli Cell Differentiation Via Disturbance of Sex Determination Pathway in Fetal and Postnatal Mice
Y Wang, Q Yang, W Liu, M Yu, Z Zhang… - Toxicological …, 2016 - academic.oup.com
Mice may share similar mechanism with human underlying reproductive toxicity induced by
di (2-ethylhexyl) phthalate (DEHP), which is not supposed to be associated with decreased …
di (2-ethylhexyl) phthalate (DEHP), which is not supposed to be associated with decreased …