Drugs of abuse produce widespread effects on the structure and function of neurons
throughout the brain's reward circuitry, and these changes are believed to underlie the long …

Drug addiction is a chronic brain disease and drugs of abuse cause long lasting
neuroadaptations. Addiction is characterized by the loss of control over drug use despite …

The effects of brain-derived neurotrophic factor (BDNF) on cocaine-seeking are brain region-
specific. Infusion of BDNF into subcortical structures, like the nucleus accumbens and …

Brain-derived neurotrophic factor (BDNF) has been found to play roles in many types of
plasticity including drug addiction. Here, we focus on rodent studies over the past two …

Cocaine addiction is one of the severest health problems faced by western countries, where
there is an increasing prevalence of lifelong abuse. The most challenging aspects in the …

Brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor
(GDNF) are neurotrophic factors that are critical for the growth, survival, and differentiation of …

Neurotrophins are critical to the development and maintenance of the mammalian central
nervous system. Among them is brain‐derived neurotrophic factor (BDNF), whose synthesis …

Brain-derived neurotrophic factor (BDNF) contributes to diverse types of plasticity, including
cocaine addiction. We investigated the role of BDNF in the rat nucleus accumbens (NAc) in …

Many abused drugs lead to changes in endogenous brain-derived neurotrophic factor
(BDNF) expression in neural circuits responsible for addictive behaviors. BDNF is a known …

Neurotrophins are important regulators of neuronal function in the developing and adult
brain and thus play a critical role in sustaining normal behavioral function. Brain-derived …