Introduction: Infections due to multidrug-resistant (MDR) bacteria are burdened by high
mortality rates. The development of new compounds to face the global threat of resistance is …

Background: Infections caused by multi-drug resistant (MDR) Gram-negative bacteria
represent an ever-growing area of unmet medical need. To address this need, it is …

Eradicating multi-drug resistant (MDR) organisms has been a major challenge in healthcare
settings worldwide. Newly approved drugs and those currently in the pipeline may have a …

The spread of multidrug-resistant bacteria is an ever-growing concern, particularly among
Gram-negative bacteria because of their intrinsic resistance and how quickly they acquire …

Microbial resistance is a serious threat to human health worldwide. Among the World Health
Organisation's list of priority resistant bacteria, three are listed as critical—the highest level of …

Encountering multidrug-resistant (MDR) Gram-negative infections in critically ill patients has
become an all-too-common occurrence in healthcare settings. Increasingly, clinicians are …

Bacterial resistance to antimicrobial agents is a growing problem worldwide. Not only is
issue compounded by the fact that there are fewer pharmaceutical companies conducting …

The past decade has brought a significant rise in antimicrobial resistance, and the ESKAPE
pathogens have become a significant threat to public health. Three epidemiological features …

Highlights•Agents targeting resistant Gram-negative bacteria are in the antibacterial
pipeline.•Both broad and narrow spectrum agents are in clinical development.•Public …

Introduction: The constantly increasing spread of severe infections due to multidrug-resistant
(MDR) Gram-negative bacteria (GNB) is a critical threat to the global medical community …