Objectives Opiorphin is a recently discovered peptide shown to inhibit the enkephalin-
degrading enzymes and prolong the effects of enkephalins. Although opiorphin is found in …

Objectives: Opiorphin is an enkephalinase inhibitor which suppresses pain by acting on the
opioid system. The levels of opiorphin in plasma and saliva have shown to vary in patients …

Objective Opiorphin is a pentapeptide secreted in saliva and has a strong analgesic effect.
Salivary opiorphin has been shown to increase in orofacial pain and may act as a pain …

Purpose This study aimed at assessing the change in salivary opiorphin levels before and
after administration of local anesthesia, with the use of three different local anesthetic …

Objectives Opiorphin is a pentapeptide isolated from human saliva that suppresses pain
from chemically induced inflammation and acute physical pain. Burning mouth syndrome …

Opiorphin, QRFSR-peptide, is a mature product of the PROL1 (proline rich, lacrimal 1)
protein that showed beneficial effects in pain management, antidepressant-like actions as …

Objectives: Opiorphin is a physiological inhibitor of peptidases inactivating endogenous
opioids displaying strong analgesic properties without undesirable side effects …

Background: Opiorphin is an endogenous human peptide regulator of enkephalin
bioavailability. It inhibits enkephalin-inactivating ectopeptidases to produce analgesia and …

Mammalian zinc ectopeptidases play important roles in turning off neural and hormonal
peptide signals at the cell surface, notably those processing sensory information. We report …

Human opiorphin protects enkephalins from degradation by human neutral endopeptidase
and aminopeptidase-N and inhibits pain perception in various behavioral rodent models of …